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Literature summary extracted from

  • Danielsson, K.; Rydberg, E.; Ingelsten, M.; Akyuerek, L.; Jirholt, P.; Ullstroem, C.; Forsberg, G.; Boren, J.; Wiklund, O.; Hulten, L.
    15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration (2008), Atherosclerosis, 199, 34-40.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.33 overexpression of 15-LOX-2 in human macrophages by adenovirus-mediated gene delivery Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.33 siRNA knockdown of 15-LOX-2 expression, decreases chemokine ligand CXCL10 secretion from hypoxic macrophages and reduces T cell migration and CD69 expression Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 15-lipoxygenase-2
-
 Homo sapiens
1.13.11.33 15-LOX-2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.13.11.33 physiological function macrophages that overexpress 15-LOX-2 show increased secretion of chemokine ligands CXCL10 and CCL2 after 24h incubation. Preconditioned medium from 15-LOX-2-overexpressing cells increases T cell migration, the expression of T cell activation marker CD69 and surface expression of chemokine receptor CXCR3, the CXCL10 chemokine ligand. Increased expression of 15-LOX-2 induced by hypoxia may participate in T cell recruitment in diseases such as atherosclerosis Homo sapiens