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Literature summary extracted from

  • Lidington, D.; Peter, B.F.; Meissner, A.; Kroetsch, J.T.; Pitson, S.M.; Pohl, U.; Bolz, S.S.
    The phosphorylation motif at serine 225 governs the localization and function of sphingosine kinase 1 in resistance arteries (2009), Arterioscler. Thromb. Vasc. Biol., 29, 1916-1922.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.91 S225A expression in resistance artery smooth muscle cells reduces resting and myogenic tone, resting Ca2+, pressure-induced Ca2+ elevations, and Ca2+ sensitivity. Lack of function of S225A can only partly be overcome by forced localization to the plasma membrane Mesocricetus auratus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.91 Mesocricetus auratus
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Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.91 phosphoprotein in muscle resistance artery, pressure-dependent activation and translocation of isoform Sk1 by ERK1/2 is critically dependent on its serine225 phosphorylation site Mesocricetus auratus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.91 artery gracilis muscle resistance artery. Pressure-dependent activation and translocation of isoform Sk1 by ERK1/2 is critically dependent on its serine225 phosphorylation site Mesocricetus auratus
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2.7.1.91 smooth muscle gracilis muscle resistance artery. Pressure-dependent activation and translocation of isoform Sk1 by ERK1/2 is critically dependent on its serine225 phosphorylation site Mesocricetus auratus
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General Information

EC Number General Information Comment Organism
2.7.1.91 physiological function translocation and precise subcellular positioning of Sk1 is essential for full function, and two distinct sphingosin 1-phosphate pools, intra- and extracellular, contribute to the maintenance of vascular tone Mesocricetus auratus