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Literature summary extracted from

  • Nagelin, M.H.; Srinivasan, S.; Lee, J.; Nadler, J.L.; Hedrick, C.C.
    12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1 (2008), Arterioscler. Thromb. Vasc. Biol., 28, 1811-1819.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.31 12/15LO stably overexpressed in mouse J774 macrophages Sus scrofa
1.13.11.33 12/15LO stably overexpressed in mouse J774 macrophages Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Sus scrofa
-
-
-
1.13.11.33 Sus scrofa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.31 arachidonate + O2
-
 Sus scrofa (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate 12/15LO eicosanoid products reduce cholesterol efflux to high density lipoproteins, regulate ATP-binding cassette transporter G1 expression and enhance ATP-binding cassette transporter G1 degradation and ATP-binding cassette transporter G1 serine phosphorylation ?
1.13.11.33 arachidonate + O2
-
 Sus scrofa (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate 12/15LO eicosanoid products reduce cholesterol efflux to high density lipoproteins, regulate ATP-binding cassette transporter G1 expression and enhance ATP-binding cassette transporter G1 degradation and ATP-binding cassette transporter G1 serine phosphorylation ?
1.13.11.33 linoleic acid + O2
-
 Sus scrofa 13(S)-hydroxyoctadecadienoic acid 12/15LO eicosanoid products reduce cholesterol efflux to high density lipoproteins, regulate ATP-binding cassette transporter G1 expression and enhance ATP-binding cassette transporter G1 degradation and ATP-binding cassette transporter G1 serine phosphorylation ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.31 12/15-lipoxygenase
-
 Sus scrofa
1.13.11.31 12/15LO
-
 Sus scrofa
1.13.11.33 12/15-lipoxygenase
-
 Sus scrofa
1.13.11.33 12/15LO
-
 Sus scrofa

General Information

EC Number General Information Comment Organism
1.13.11.31 physiological function 12/15LO activity in the vessel wall contributes to atherogenesis by impairing the macrophage ATP-binding cassette transporter G1 cholesterol efflux pathway. 12/15LO activity reduces high density lipoprotein-mediated cholesterol efflux, ATP-binding cassette transporter G1 cellular expression. 12/15LO activity does not affect ATP-binding cassette transporter G1 mRNA expression Sus scrofa
1.13.11.33 physiological function 12/15LO activity in the vessel wall contributes to atherogenesis by impairing the macrophage ATP-binding cassette transporter G1 cholesterol efflux pathway. 12/15LO activity reduces high density lipoprotein-mediated cholesterol efflux, ATP-binding cassette transporter G1 cellular expression. 12/15LO activity does not affect ATP-binding cassette transporter G1 mRNA expression Sus scrofa