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Literature summary extracted from
- Single-nucleotide polymorphic variants of human glutathione transferase T1-1 differ in stability and functional properties (2009), Arch. Biochem. Biophys., 490, 24-29.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 2.5.1.18 | D141N | site-directed mutagenesis of isozyme GST T1-1, the mutant enzyme behaves similarly to the wild-type enzyme, in terms of expression level and specific activity. The mutant activity with ethidium bromide is highly reduced compared to the wild-type enzyme | Homo sapiens |
| 2.5.1.18 | E173K | site-directed mutagenesis of isozyme GST T1-1, the mutant shows reduced expression levels and enzyme activity with all substrates compared to the wild-type enzyme. The mutant is not active with ethidium bromide | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.5.1.18 | S-hexyl glutathione | - |
Homo sapiens |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.5.1.18 | Homo sapiens | P30711 | isozyme GST T1-1 | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.5.1.18 | glutathione + 1,2-epoxy-3-(p-nitrophenoxy)propane | - |
Homo sapiens | ? | - |
? | |
| 2.5.1.18 | glutathione + 4-nitrobenzyl chloride | - |
Homo sapiens | S-(4-nitrobenzyl)glutathione + HCl | - |
? | |
| 2.5.1.18 | glutathione + ethylene diiodide | - |
Homo sapiens | ? | - |
? | |
| 2.5.1.18 | additional information | GST T1-1 displays both glutathione transferase and glutathione peroxidase enzyme activities, the latter with CuOOH | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.5.1.18 | glutathione transferase T1-1 | - |
Homo sapiens |
| 2.5.1.18 | GST T1-1 | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 2.5.1.18 | 30 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 2.5.1.18 | 8 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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