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Literature summary extracted from

  • Meigs, T.E.; Simoni, R.D.
    Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase (1997), Arch. Biochem. Biophys., 345, 1-9.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.7.6 up enzyme activity increases under conditions of increased metabolic flow through the isoprenoid pathway Cricetulus griseus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.7.6 (2E,6E)-farnesyl diphosphate competitive Cricetulus griseus
3.1.7.6 farnesyl diphosphate 0.25 mM, 80% inhibition Cricetulus griseus
3.1.7.6 farnesyl monophosphate 0.07 mM, 35% inhibition Cricetulus griseus
3.1.7.6 geranylgeranyl diphosphate 0.05 mM, 60% inhibition Cricetulus griseus
3.1.7.6 NaF 100 mM, about 70% inhibition Cricetulus griseus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.7.6 0.015
-
 (2E,6E)-farnesyl diphosphate pH 5.5, 37°C Cricetulus griseus

Organism

EC Number Organism UniProt Comment Textmining
3.1.7.6 Cricetulus griseus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.7.6 (2E,6E)-farnesyl diphosphate + H2O
-
 Cricetulus griseus (2E,6E)-farnesol + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.7.6 farnesyl pyrophosphatase
-
 Cricetulus griseus
3.1.7.6 FPPase
-
 Cricetulus griseus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.7.6 37
-
 assay at Cricetulus griseus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.7.6 5.5
-
 assay at Cricetulus griseus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.7.6 0.37
-
 (2E,6E)-farnesyl diphosphate pH 5.5, 37°C Cricetulus griseus