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Literature summary extracted from
- b-Type dihydroorotate dehydrogenase is purified as a H2O2-forming NADH oxidase from Bifidobacterium bifidum (2009), Appl. Environ. Microbiol., 75, 629-636.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.14 | Hg2+ | complete inhibition of both orotate reductase and NADH oxidase reaction | Bifidobacterium bifidum |  |
| 1.3.1.14 | KCN | complete inhibition of orotate reductase reaction | Bifidobacterium bifidum | |
| 1.3.1.14 | p-chloromercuribenzoate | complete inhibition of both orotate reductase and NADH oxidase reaction | Bifidobacterium bifidum | |
| 1.3.1.14 | Quinacrine | 19.2% inhibition of orotate reductase reaction | Bifidobacterium bifidum | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.3.1.14 | 130000 | - |
gel filtration | Bifidobacterium bifidum |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.1.14 | Bifidobacterium bifidum | B7X933 | subunit PyrDb; bifunctional orotate reductase and H2O2-forming NADH oxidase | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.3.1.14 | - |
Bifidobacterium bifidum |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.3.1.14 | tetramer | 2 * subunit PyrDb plus 2 * subunit PyrK | Bifidobacterium bifidum |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.3.1.14 | b-type dihydroorotate dehydrogenase | - |
Bifidobacterium bifidum |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.3.1.14 | 6.5 | - |
and 7.5, NADH oxidase reaction | Bifidobacterium bifidum |
| 1.3.1.14 | 7.5 | - |
and 6.5, NADH oxidase reaction and dihydrorotate oxidase reaction | Bifidobacterium bifidum |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.3.1.14 | 6.5 | - |
70% of maximal activity, dihydrorotate oxidase reaction | Bifidobacterium bifidum |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.14 | FAD | - |
Bifidobacterium bifidum | |
| 1.3.1.14 | FMN | - |
Bifidobacterium bifidum | |
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Release 2023.1 (January 2023)
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