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Literature summary extracted from

  • He, C.; Choi, H.C.; Xie, Z.
    Enhanced tyrosine nitration of prostacyclin synthase is associated with increased inflammation in atherosclerotic carotid arteries from type 2 diabetic patients (2010), Am. J. Pathol., 176, 2542-2549.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
5.3.99.4 medicine tyrosine nitration of prostacyclin synthase is correlated with an excessive inflammatory response in atherosclerotic carotid arteries from patients with type 2 diabetes Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.4 Prostaglandin H2 Homo sapiens
-
 Prostaglandin I2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.4 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
5.3.99.4 additional information diabetes induces prostacyclin synthase nitration in carotid plaques Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.4 aortic endothelial cell HAEC Homo sapiens
-
5.3.99.4 carotid artery
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.4 Prostaglandin H2
-
 Homo sapiens Prostaglandin I2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.4 PGIS
-
 Homo sapiens
5.3.99.4 prostacyclin synthase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
5.3.99.4 Homo sapiens hyperglycemia and palmitate increase prostacyclin synthase nitration and reduce its activity down