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Literature summary extracted from

  • Shimura, C.; Satoh, T.; Igawa, K.; Aritake, K.; Urade, Y.; Nakamura, M.; Yokozeki, H.
    Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin (2010), Am. J. Pathol., 176, 227-237.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.3.99.2 phorbol 12-myrisate 13-acetate
-
 Homo sapiens
5.3.99.2 thymic stromal lymphopoietin stimulates mRNA synthesis Homo sapiens

Application

EC Number Application Comment Organism
5.3.99.2 medicine dendritic cells in the epidermis and dermis are capable of functioning as an important source of PGD2 in the skin, thereby contributing to or regulating innate and/or acquired immune responses of the skin Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.99.2 26000
-
 determined by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.2 Prostaglandin H2 Homo sapiens
-
 Prostaglandin D2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.2 dendritic cell
-
 Homo sapiens
-
5.3.99.2 dermal dendritic cell
-
 Homo sapiens
-
5.3.99.2 Langerhans cell epidermal Langerhans cell Homo sapiens
-
5.3.99.2 myeloid dendritic cell
-
 Homo sapiens
-
5.3.99.2 plasmacytoid dendritic cell
-
 Homo sapiens
-
5.3.99.2 skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.2 Prostaglandin H2
-
 Homo sapiens Prostaglandin D2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.2 H-PGDS
-
 Homo sapiens
5.3.99.2 Hematopoietic prostaglandin D synthase
-
 Homo sapiens
5.3.99.2 Prostaglandin D synthase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
5.3.99.2 Homo sapiens lipopolysaccharide, LPS, reduces H-PGDS expression down