BRENDA - Enzyme Database show

Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin

Shimura, C.; Satoh, T.; Igawa, K.; Aritake, K.; Urade, Y.; Nakamura, M.; Yokozeki, H.; Am. J. Pathol. 176, 227-237 (2010)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
5.3.99.2
phorbol 12-myrisate 13-acetate
-
Homo sapiens
5.3.99.2
thymic stromal lymphopoietin
stimulates mRNA synthesis
Homo sapiens
Application
EC Number
Application
Commentary
Organism
5.3.99.2
medicine
dendritic cells in the epidermis and dermis are capable of functioning as an important source of PGD2 in the skin, thereby contributing to or regulating innate and/or acquired immune responses of the skin
Homo sapiens
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.3.99.2
26000
-
determined by SDS-PAGE and Western Blot analysis
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.2
Prostaglandin H2
Homo sapiens
-
Prostaglandin D2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.2
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.2
dendritic cell
-
Homo sapiens
-
5.3.99.2
dermal dendritic cell
-
Homo sapiens
-
5.3.99.2
Langerhans cell
epidermal Langerhans cell
Homo sapiens
-
5.3.99.2
myeloid dendritic cell
-
Homo sapiens
-
5.3.99.2
plasmacytoid dendritic cell
-
Homo sapiens
-
5.3.99.2
skin
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
701618
Homo sapiens
Prostaglandin D2
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
5.3.99.2
phorbol 12-myrisate 13-acetate
-
Homo sapiens
5.3.99.2
thymic stromal lymphopoietin
stimulates mRNA synthesis
Homo sapiens
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.2
medicine
dendritic cells in the epidermis and dermis are capable of functioning as an important source of PGD2 in the skin, thereby contributing to or regulating innate and/or acquired immune responses of the skin
Homo sapiens
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.3.99.2
26000
-
determined by SDS-PAGE and Western Blot analysis
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.2
Prostaglandin H2
Homo sapiens
-
Prostaglandin D2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.2
dendritic cell
-
Homo sapiens
-
5.3.99.2
dermal dendritic cell
-
Homo sapiens
-
5.3.99.2
Langerhans cell
epidermal Langerhans cell
Homo sapiens
-
5.3.99.2
myeloid dendritic cell
-
Homo sapiens
-
5.3.99.2
plasmacytoid dendritic cell
-
Homo sapiens
-
5.3.99.2
skin
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.2
Prostaglandin H2
-
701618
Homo sapiens
Prostaglandin D2
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
5.3.99.2
Homo sapiens
lipopolysaccharide, LPS, reduces H-PGDS expression
down
Expression (protein specific)
EC Number
Organism
Commentary
Expression
5.3.99.2
Homo sapiens
lipopolysaccharide, LPS, reduces H-PGDS expression
down