BRENDA - Enzyme Database

Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression

Merida, I.; Avila-Flores, A.; Garcia, J.; Merino, E.; Almena, M.; Torres-Ayuso, P.; Adv. Enzyme Regul. 49, 174-188 (2009)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.107
cholesterol
DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such cholesterol
Homo sapiens
2.7.1.107
cholesterol
DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such cholesterol
Mus musculus
2.7.1.107
P53
p53 activates DGKalpha in response to DNA damage
Homo sapiens
2.7.1.107
P53
p53 activates DGKalpha in response to DNA damage
Mus musculus
2.7.1.107
phosphatidylethanolamine
DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such as phosphatidylethanolamine
Homo sapiens
2.7.1.107
phosphatidylethanolamine
DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such as phosphatidylethanolamine
Mus musculus
General Stability
EC Number
General Stability
Organism
2.7.1.107
activation of tyrosine kinases is required for membrane stabilization of DGKalpha, phosphorylation of DGKalpha at Tyr335 appears to be essential for membrane localization
Homo sapiens
2.7.1.107
activation of tyrosine kinases is required for membrane stabilization of DGKalpha, phosphorylation of DGKalpha at Tyr335 appears to be essential for membrane localization
Mus musculus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.107
cytosol
DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function
Homo sapiens
5829
-
2.7.1.107
cytosol
DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function
Mus musculus
5829
-
2.7.1.107
membrane
DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function
Homo sapiens
16020
-
2.7.1.107
membrane
DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function
Mus musculus
16020
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.107
Ca2+
Ca2+ requirement in DGKalpha activation
Homo sapiens
2.7.1.107
Ca2+
Ca2+ requirement in DGKalpha activation
Mus musculus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.107
Homo sapiens
P23743
-
-
2.7.1.107
Mus musculus
O88673
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.107
brain
high expression
Mus musculus
-
2.7.1.107
endothelial cell
-
Homo sapiens
-
2.7.1.107
endothelial cell
-
Mus musculus
-
2.7.1.107
heart
low expression
Mus musculus
-
2.7.1.107
kidney
low expression
Mus musculus
-
2.7.1.107
liver
low expression
Mus musculus
-
2.7.1.107
lung
high expression
Mus musculus
-
2.7.1.107
oligodendrocyte
DGKalpha is expressed predominantly in oligodendrocytes
Homo sapiens
-
2.7.1.107
oligodendrocyte
DGKalpha is expressed predominantly in oligodendrocytes
Mus musculus
-
2.7.1.107
spleen
high expression
Mus musculus
-
2.7.1.107
T-lymphocyte
particularly enriched in peripheral T lymphocytes
Homo sapiens
-
2.7.1.107
T-lymphocyte
particularly enriched in peripheral T lymphocytes
Mus musculus
-
2.7.1.107
testis
high expression
Mus musculus
-
2.7.1.107
thymus
particularly enriched in thymus
Homo sapiens
-
2.7.1.107
thymus
particularly enriched in thymus
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.107
ATP + 1,2-diacylglycerol
-
701582
Homo sapiens
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
2.7.1.107
ATP + 1,2-diacylglycerol
-
701582
Mus musculus
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.107
ATP
-
Mus musculus
2.7.1.107
ATP
-
Homo sapiens
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.107
cholesterol
DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such cholesterol
Homo sapiens
2.7.1.107
cholesterol
DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such cholesterol
Mus musculus
2.7.1.107
P53
p53 activates DGKalpha in response to DNA damage
Homo sapiens
2.7.1.107
P53
p53 activates DGKalpha in response to DNA damage
Mus musculus
2.7.1.107
phosphatidylethanolamine
DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such as phosphatidylethanolamine
Homo sapiens
2.7.1.107
phosphatidylethanolamine
DGKalpha can be activated in vitro in a Ca2+-independent manner by lipids such as phosphatidylethanolamine
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.107
ATP
-
Mus musculus
2.7.1.107
ATP
-
Homo sapiens
General Stability (protein specific)
EC Number
General Stability
Organism
2.7.1.107
activation of tyrosine kinases is required for membrane stabilization of DGKalpha, phosphorylation of DGKalpha at Tyr335 appears to be essential for membrane localization
Homo sapiens
2.7.1.107
activation of tyrosine kinases is required for membrane stabilization of DGKalpha, phosphorylation of DGKalpha at Tyr335 appears to be essential for membrane localization
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.107
cytosol
DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function
Homo sapiens
5829
-
2.7.1.107
cytosol
DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function
Mus musculus
5829
-
2.7.1.107
membrane
DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function
Homo sapiens
16020
-
2.7.1.107
membrane
DGKalpha is a cytosolic enzyme that must relocate to the membrane in response to receptor stimulation to exercise its function
Mus musculus
16020
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.107
Ca2+
Ca2+ requirement in DGKalpha activation
Homo sapiens
2.7.1.107
Ca2+
Ca2+ requirement in DGKalpha activation
Mus musculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.107
brain
high expression
Mus musculus
-
2.7.1.107
endothelial cell
-
Homo sapiens
-
2.7.1.107
endothelial cell
-
Mus musculus
-
2.7.1.107
heart
low expression
Mus musculus
-
2.7.1.107
kidney
low expression
Mus musculus
-
2.7.1.107
liver
low expression
Mus musculus
-
2.7.1.107
lung
high expression
Mus musculus
-
2.7.1.107
oligodendrocyte
DGKalpha is expressed predominantly in oligodendrocytes
Homo sapiens
-
2.7.1.107
oligodendrocyte
DGKalpha is expressed predominantly in oligodendrocytes
Mus musculus
-
2.7.1.107
spleen
high expression
Mus musculus
-
2.7.1.107
T-lymphocyte
particularly enriched in peripheral T lymphocytes
Homo sapiens
-
2.7.1.107
T-lymphocyte
particularly enriched in peripheral T lymphocytes
Mus musculus
-
2.7.1.107
testis
high expression
Mus musculus
-
2.7.1.107
thymus
particularly enriched in thymus
Homo sapiens
-
2.7.1.107
thymus
particularly enriched in thymus
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.107
ATP + 1,2-diacylglycerol
-
701582
Homo sapiens
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
2.7.1.107
ATP + 1,2-diacylglycerol
-
701582
Mus musculus
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
2.7.1.107
Homo sapiens
p53-mediated upregulation of DGKalpha mRNA in human-derived cells, (PPAR)-gamma-dependent DGKalpha upregulation in endothelial cells, DMSO-based differentiation of promyelocytic HL-60 cells into a neutrophilic phenotype correlates with increase in the expression of DGKalpha, DGKalpha expression is upregulated in cancer
up
2.7.1.107
Mus musculus
p53-mediated upregulation of DGKalpha mRNA in mouse-derived cells, (PPAR)-gamma-dependent DGKalpha upregulation in endothelial cells, DMSO-based differentiation of promyelocytic HL-60 cells into a neutrophilic phenotype correlates with increase in the expression of DGKalpha, DGKalpha expression is upregulated in cancer
up
General Information
EC Number
General Information
Commentary
Organism
2.7.1.107
physiological function
membrane localization of DGKalpha acts as a switch-off signal for Ras activation, mediated by localization to the membrane of Ras-GRP1, DGKalpha is a negative regulator of the T cell activation program, DGKalpha activity is required for optimal chemotactic response of neutrophils, whereas it halts their oxidative burst, DGKalpha is a negative modulator of diacylglycerol signaling, DGKalpha activity modulates the mTOR pathway to prevent cell cycle transition, DGKalpha is an indicator of cell quiescence, DGKalpha is a positive regulator of cell proliferation and migration
Homo sapiens
2.7.1.107
physiological function
membrane localization of DGKalpha acts as a switch-off signal for Ras activation, mediated by localization to the membrane of Ras-GRP1, DGKalpha is a negative regulator of the T cell activation program, DGKalpha activity is required for optimal chemotactic response of neutrophils, whereas it halts their oxidative burst, DGKalpha is a negative modulator of diacylglycerol signaling, DGKalpha activity modulates the mTOR pathway to prevent cell cycle transition, DGKalpha is an indicator of cell quiescence, DGKalpha is a positive regulator of cell proliferation and migration
Mus musculus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
2.7.1.107
physiological function
membrane localization of DGKalpha acts as a switch-off signal for Ras activation, mediated by localization to the membrane of Ras-GRP1, DGKalpha is a negative regulator of the T cell activation program, DGKalpha activity is required for optimal chemotactic response of neutrophils, whereas it halts their oxidative burst, DGKalpha is a negative modulator of diacylglycerol signaling, DGKalpha activity modulates the mTOR pathway to prevent cell cycle transition, DGKalpha is an indicator of cell quiescence, DGKalpha is a positive regulator of cell proliferation and migration
Homo sapiens
2.7.1.107
physiological function
membrane localization of DGKalpha acts as a switch-off signal for Ras activation, mediated by localization to the membrane of Ras-GRP1, DGKalpha is a negative regulator of the T cell activation program, DGKalpha activity is required for optimal chemotactic response of neutrophils, whereas it halts their oxidative burst, DGKalpha is a negative modulator of diacylglycerol signaling, DGKalpha activity modulates the mTOR pathway to prevent cell cycle transition, DGKalpha is an indicator of cell quiescence, DGKalpha is a positive regulator of cell proliferation and migration
Mus musculus
Expression (protein specific)
EC Number
Organism
Commentary
Expression
2.7.1.107
Homo sapiens
p53-mediated upregulation of DGKalpha mRNA in human-derived cells, (PPAR)-gamma-dependent DGKalpha upregulation in endothelial cells, DMSO-based differentiation of promyelocytic HL-60 cells into a neutrophilic phenotype correlates with increase in the expression of DGKalpha, DGKalpha expression is upregulated in cancer
up
2.7.1.107
Mus musculus
p53-mediated upregulation of DGKalpha mRNA in mouse-derived cells, (PPAR)-gamma-dependent DGKalpha upregulation in endothelial cells, DMSO-based differentiation of promyelocytic HL-60 cells into a neutrophilic phenotype correlates with increase in the expression of DGKalpha, DGKalpha expression is upregulated in cancer
up