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Literature summary extracted from

  • Reh, R.; Ozols, J.; Clement, B.
    Involvement of stearoyl-CoA desaturase in the reduction of amidoxime prodrugs (2008), Xenobiotica, 38, 1177-1190.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.1 cytochrome c
-
 Rattus norvegicus
1.14.19.1 cytochrome c very low inhibitor concentrations of 10 mM lead to an almost complete inhibition of the SCD benzamidoxime reductase activity of porcine adipose tissue microsome Sus scrofa
1.14.19.1 p-hydroxymercuribenzoate
-
 Rattus norvegicus
1.14.19.1 p-hydroxymercuribenzoate potent inhibitor of the SCD benzamidoxime reductase activity of porcine adipose tissue microsomes Sus scrofa
1.14.19.1 potassium cyanide
-
 Rattus norvegicus
1.14.19.1 potassium cyanide supplementation of potassium cyanide leads to a 65% inhibition of the microsomal benzamidoxime reductase activity of SCD in porcine adipose tissue Sus scrofa
1.14.19.1 potassium hexacyanoferrate
-
 Rattus norvegicus
1.14.19.1 potassium hexacyanoferrate
-
 Sus scrofa
1.14.19.1 stearoyl-CoA inhibits SCD activity in concentrations greater than 0.05 mM Rattus norvegicus
1.14.19.1 stearoyl-CoA inhibits SCD activity in concentrations greater than 0.05 mM Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.1 microsome
-
 Rattus norvegicus
-
-
1.14.19.1 microsome
-
 Sus scrofa
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.19.1 37000
-
 SDS-PAGE Rattus norvegicus
1.14.19.1 41000
-
 SDS-PAGE Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Rattus norvegicus
-
-
-
1.14.19.1 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.19.1
-
 Rattus norvegicus
1.14.19.1
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 adipose tissue
-
 Rattus norvegicus
-
1.14.19.1 adipose tissue
-
 Sus scrofa
-
1.14.19.1 liver
-
 Rattus norvegicus
-
1.14.19.1 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 N-hydroxy-benzenecarboximidamide + NADH + H+ + O2
-
 Rattus norvegicus benzamidine + NAD+ + H2O
-
 ?
1.14.19.1 N-hydroxy-benzenecarboximidamide + NADH + H+ + O2
-
 Sus scrofa benzamidine + NAD+ + H2O
-
 ?
1.14.19.1 stearoyl-CoA + NADH + H+ + O2
-
 Rattus norvegicus oleoyl-CoA + NAD+ + H2O
-
 ?
1.14.19.1 stearoyl-CoA + NADH + H+ + O2
-
 Sus scrofa oleoyl-CoA + NAD+ + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.19.1 ? x * 37000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD
-
 Rattus norvegicus
1.14.19.1 SCD
-
 Sus scrofa
1.14.19.1 stearoyl-CoA desaturase
-
 Rattus norvegicus
1.14.19.1 stearoyl-CoA desaturase
-
 Sus scrofa

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.14.19.1 0.0000019
-
 N-hydroxy-benzenecarboximidamide at 37°C Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 NADH
-
 Rattus norvegicus
1.14.19.1 NADH
-
 Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.19.1 0.0018
-
 at 37°C Sus scrofa cytochrome c
1.14.19.1 0.2
-
 at 37°C Sus scrofa stearoyl-CoA
1.14.19.1 0.229
-
 at 37°C Sus scrofa potassium hexacyanoferrate
1.14.19.1 0.3
-
 at 37°C Sus scrofa potassium cyanide