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Literature summary extracted from

  • Nasralla, S.N.; Ghoneim, A.I.; Khalifa, A.E.; Gad, M.Z.; Abdel-Naim, A.B.
    Lactoperoxidase catalyzes in vitro activation of acrylonitrile to cyanide (2009), Toxicol. Lett., 191, 347-352.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.11.1.7 D-penicillamine D-penicillamine achieves 128.3% of the rate of cyanide production of the control in the LPO/H2O2/acetonitrile system Bos taurus
1.11.1.7 glutathione glutathione achieves 138.8% of the rate of cyanide production of the control in the LPO/H2O2/acetonitrile system Bos taurus
1.11.1.7 L-cysteine L-cysteine is associated with the highest boost in the rate of cyanide formation in the LPO/H2O2/acetonitrile system, achieving 156.7% of the rate of cyanide production of the control Bos taurus
1.11.1.7 N-acetylcysteine N-acetylcysteine achieves 123.4% of the rate of cyanide production of the control in the LPO/H2O2/acetonitrile system Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.1.7 indomethacin the presence of indomethacin in the LPO/H2O2/acetonitrile system leads to a modest, yet significant decline in the rate of cyanide formation of only 84.1% of the control Bos taurus
1.11.1.7 quercetin incubation of the LPO/H2O2/acetonitrile system with 0.1 mM quercetin is associated with the highest rate of inhibition amounting to 40.2% of the control Bos taurus
1.11.1.7 resorcinol incubation of the LPO/H2O2/acetonitrile system with resorcinol is associated with amoderate decline in the rate of cyanide production which is 64.8% of the control Bos taurus
1.11.1.7 Sodium azide incubation of the LPO/H2O2/acetonitrile system with sodium azide is associated with amoderate decline in the rate of cyanide production which is 61.6% of the control Bos taurus
1.11.1.7 trolox C incubation of the LPO/H2O2/acetonitrile system with 0.1 mM trolox C is associated with the highest rate of inhibition amounting to 47.8% of the control Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.7 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.1.7 milk
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.11.1.7 additional information
-
 the maximal rate of cyanide generation observed at pH 5.0 and 37°C is 139.7 pmol/ml/min on average Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.7 acrylonitrile + H2O2
-
 Bos taurus cyanide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.7 lactoperoxidase
-
 Bos taurus
1.11.1.7 LPO
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.11.1.7 37
-
 the highest rate of cyanide formation is recorded at a temperature of 37°C Bos taurus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.11.1.7 15 60 LPO enzyme activity is retained between 15°C and 60°C Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.11.1.7 5
-
 the highest rate of cyanide formation is recorded at pH 5.0 Bos taurus