EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.120 | 4-hydroxybutanoyl-CoA | Metallosphaera sedula | - |
but-3-enoyl-CoA + H2O | - |
? | |
6.2.1.36 | 3-hydroxypropanoate + ATP + coenzyme A | Metallosphaera sedula | the enzyme is involved in the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle (autotrophic carbon dioxide assimilation pathway in archaea) | 3-hydroxypropanoyl-CoA + AMP + diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.298 | Metallosphaera sedula | - |
- |
- |
4.2.1.120 | Metallosphaera sedula | - |
- |
- |
6.2.1.36 | Metallosphaera sedula | A4YGR1 | - |
- |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.1.1.298 | 1.5 | - |
65°C | Metallosphaera sedula |
4.2.1.120 | 0.04 | - |
65°C | Metallosphaera sedula |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.298 | malonate semialdehyde + NADPH | - |
Metallosphaera sedula | 3-hydroxypropionate + NADP+ | - |
? | |
4.2.1.120 | 4-hydroxybutanoyl-CoA | - |
Metallosphaera sedula | but-3-enoyl-CoA + H2O | - |
? | |
6.2.1.36 | 3-hydroxypropanoate + ATP + coenzyme A | - |
Metallosphaera sedula | 3-hydroxypropanoyl-CoA + AMP + diphosphate | - |
? | |
6.2.1.36 | 3-hydroxypropanoate + ATP + coenzyme A | the enzyme is involved in the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle (autotrophic carbon dioxide assimilation pathway in archaea) | Metallosphaera sedula | 3-hydroxypropanoyl-CoA + AMP + diphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.298 | malonate semialdehyde reductase (NADPH) | - |
Metallosphaera sedula |
6.2.1.36 | 3-hydroxypropionyl-CoA synthetase (AMP-forming) | - |
Metallosphaera sedula |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
6.2.1.36 | 55 | - |
assay at | Metallosphaera sedula |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.298 | NADPH | - |
Metallosphaera sedula |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.1.1.298 | physiological function | enzyme is part of an autotrophic 3-hydroxypropionate/4-hydroxybutyrate carbon dioxide assimilation pathway in Metallospaera sedula. In the pathway, CO2 is fixed with acetyl-CoA/propionyl-CoA carboxylase as key carboxylating enzyme. One acetyl-CoA and two bicarbonate molecules are reductively converted via 3-hydroxypropionate to succinyl-CoA | Metallosphaera sedula |
4.2.1.120 | physiological function | enzyme is part of an autotrophic 3-hydroxypropionate/4-hydroxybutyrate carbon dioxide assimilation pathway in Metallospaera sedula. In the pathway, CO2 is fixed with acetyl-CoA/propionyl-CoA carboxylase as key carboxylating enzyme. One acetyl-CoA and two bicarbonate molecules are reductively converted via 3-hydroxypropionate to succinyl-CoA | Metallosphaera sedula |