BRENDA - Enzyme Database show

Expression patterns and role of prostaglandin-endoperoxide synthases, prostaglandin E synthases, prostacyclin synthase, prostacyclin receptor, peroxisome proliferator-activated receptor delta and retinoid x receptor alpha in rat endometrium during artificially-induced decidualization

Gillio-Meina, C.; Phang, S.H.; Mather, J.P.; Knight, B.S.; Kennedy, T.G.; Reproduction 137, 537-552 (2009)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.4
cytoplasm
-
Rattus norvegicus
5737
-
5.3.99.4
nucleus
-
Rattus norvegicus
5634
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.14.99.1
72000
-
isozyme PTGS-2
Rattus norvegicus
5.3.99.4
56500
-
determined by SDS-PAGE and Western Blot analysis
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Rattus norvegicus
-
Prostaglandin I2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.14.99.1
Rattus norvegicus
P35355
-
-
1.14.99.1
Rattus norvegicus
Q63921
-
-
5.3.99.4
Rattus norvegicus
Q62969
female Sprague-Dawley rat
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.99.1
uterine endometrium
;
Rattus norvegicus
-
5.3.99.4
endometrium
-
Rattus norvegicus
-
5.3.99.4
glandular epithelium
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
701168
Rattus norvegicus
Prostaglandin I2
-
-
-
?
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.4
cytoplasm
-
Rattus norvegicus
5737
-
5.3.99.4
nucleus
-
Rattus norvegicus
5634
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.14.99.1
72000
-
isozyme PTGS-2
Rattus norvegicus
5.3.99.4
56500
-
determined by SDS-PAGE and Western Blot analysis
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Rattus norvegicus
-
Prostaglandin I2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.99.1
uterine endometrium
-
Rattus norvegicus
-
5.3.99.4
endometrium
-
Rattus norvegicus
-
5.3.99.4
glandular epithelium
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
701168
Rattus norvegicus
Prostaglandin I2
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
1.14.99.1
Rattus norvegicus
isozyme Ptgs2 transcript level significantly increases at 2 and 4 h after the deciduogenic stimulus with sesame oil is given, and the levels return to prestimulated levels at 8, 16, and 32 h. In contrast to isoform PTGS1 protein levels, PTGS2 protein is significantly higher at 8 h and remains elevated at 16 and 32 h. PTGS2 protein levels are significantly higher in stimulated endometrium at 8 and 32 h than in nonstimulated endometrium
up
Expression (protein specific)
EC Number
Organism
Commentary
Expression
1.14.99.1
Rattus norvegicus
isozyme Ptgs2 transcript level significantly increases at 2 and 4 h after the deciduogenic stimulus with sesame oil is given, and the levels return to prestimulated levels at 8, 16, and 32 h. In contrast to isoform PTGS1 protein levels, PTGS2 protein is significantly higher at 8 h and remains elevated at 16 and 32 h. PTGS2 protein levels are significantly higher in stimulated endometrium at 8 and 32 h than in nonstimulated endometrium
up