Literature summary extracted from

Hagio, T.; Kishikawa, K.; Kawabata, K.; Tasaka, S.; Hashimoto, S.; Hasegawa, N.; Ishizaka, A.
Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters (2008), Pulm. Pharmacol. Ther., 21, 884-891.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.37	sivelestat	i.e. N-[2-[4-(2,2-dimethyl-propionyloxy)phenylsulfonylamino]benzoyl]aminoacetatetetrahydrate or ONO-5046, specific neutrophil elastase inhibitor, intravenous infusion of sivelestat at 3 mg/kg/h 0-22 h after Streptococcus pneumoniae inoculation reduces the increase in neutrophil elastase activity	Mesocricetus auratus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.37	Mesocricetus auratus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.37	bronchoalveolar lavage fluid	-	Mesocricetus auratus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.37	N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O	highly specific synthetic substrate for neutrophil elastase	Mesocricetus auratus	N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.37	neutrophil elastase	-	Mesocricetus auratus

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Release 2023.1 (January 2023)