EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.3.99.23 | peroxisome proliferator activated receptor gamma | PPARgamma | Mus musculus | |
1.3.99.23 | peroxisome proliferator activated receptor gamma | PPARgamma | Homo sapiens | |
1.3.99.23 | thiazolidinedione | - |
Mus musculus | |
1.3.99.23 | thiazolidinedione | - |
Homo sapiens |
EC Number | Application | Comment | Organism |
---|---|---|---|
1.3.99.23 | medicine | RetSat plays an important role in the biology of adipocytes, where it favors normal differentiation, yet is reduced in the obese state, RetSat is thus a novel target for therapeutic intervention in metabolic disease | Mus musculus |
1.3.99.23 | medicine | RetSat plays an important role in the biology of adipocytes, where it favors normal differentiation, yet is reduced in the obese state, RetSat is thus a novel target for therapeutic intervention in metabolic disease | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.3.99.23 | - |
Mus musculus |
1.3.99.23 | - |
Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.3.99.23 | E34A | mutant, mutation within the highly conserved region of the dinucleotide-binding motif | Mus musculus |
1.3.99.23 | E34A | mutant, mutation within the highly conserved region of the dinucleotide-binding motif | Homo sapiens |
1.3.99.23 | E96A | mutant, mutation within the highly conserved region of the dinucleotide-binding motif | Mus musculus |
1.3.99.23 | E96A | mutant, mutation within the highly conserved region of the dinucleotide-binding motif | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.3.99.23 | 60000 | - |
determined by SDS-PAGE and Western Blot analysis | Mus musculus |
1.3.99.23 | 60000 | - |
determined by SDS-PAGE and Western Blot analysis | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.99.23 | all-trans-retinol + reduced acceptor | Mus musculus | - |
all-trans-13,14-dihydroretinol + acceptor | - |
? | |
1.3.99.23 | all-trans-retinol + reduced acceptor | Homo sapiens | - |
all-trans-13,14-dihydroretinol + acceptor | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.99.23 | Homo sapiens | - |
- |
- |
1.3.99.23 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.3.99.23 | 3T3-L1 cell | - |
Mus musculus | - |
1.3.99.23 | adipocyte | - |
Mus musculus | - |
1.3.99.23 | adipocyte | - |
Homo sapiens | - |
1.3.99.23 | BOSC-23 cell | - |
Homo sapiens | - |
1.3.99.23 | HEK-293T cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.99.23 | all-trans-retinol + reduced acceptor | - |
Mus musculus | all-trans-13,14-dihydroretinol + acceptor | - |
? | |
1.3.99.23 | all-trans-retinol + reduced acceptor | - |
Homo sapiens | all-trans-13,14-dihydroretinol + acceptor | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.3.99.23 | retinol saturase | - |
Mus musculus |
1.3.99.23 | retinol saturase | - |
Homo sapiens |
1.3.99.23 | RetSat | - |
Mus musculus |
1.3.99.23 | RetSat | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.3.99.23 | FAD | FAD/NAD dinucleotide binding motif | Mus musculus | |
1.3.99.23 | FAD | FAD/NAD dinucleotide binding motif | Homo sapiens | |
1.3.99.23 | NAD+ | FAD/NAD dinucleotide binding motif | Mus musculus | |
1.3.99.23 | NAD+ | FAD/NAD dinucleotide binding motif | Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.3.99.23 | Mus musculus | in adipocytes down-regulated in obesity | down |
1.3.99.23 | Homo sapiens | in adipocytes down-regulated in obesity | down |
1.3.99.23 | Mus musculus | incubation of mature adipocytes with pioglitazone or the non-thiazolidinedione ligand GW7845 increases RetSat mRNA expression, peroxisome proliferator activated receptor gamma, PPARgamma, is required for RetSat expression in mature adipocytes | up |
1.3.99.23 | Homo sapiens | incubation of mature adipocytes with pioglitazone or the non-thiazolidinedione ligand GW7845 increases RetSat mRNA expression, peroxisome proliferator activated receptor gamma, PPARgamma, is required for RetSat expression in mature adipocytes | up |