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Literature summary extracted from

  • Gallazzini, M.; Ferraris, J.D.; Burg, M.B.
    GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC (2008), Proc. Natl. Acad. Sci. USA, 105, 11026-11031.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.44 expression in mIMCD-3 cell: GDPD5 expression reduces (mRNA level) when osmolarity is increased from 300 to 700 mosmol/kg by adding NaCl (200 mosmol/kg) and urea (200 mosmol/kg) in combination. HEK293 cells transfected with GDPD5: recombinant GDPD5 is perinuclear. GDPD5 colocalizes with neuropathy target esterase in the ER of HEK293 cells. Expression of GDPD5 increases GPC-PDE activity (specific siRNA assay to knock down GDPD5, mIMCD-3 cells) Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.44 Urea in vivo: activity decreases in vivo (mIMCD-3 cell), measuring choline by chemiluminescence, substrate sn-glycero-3-phosphocholine. in vitro: no directl inhibition of GDPD5 activity, GPC-PDE in vitro activity is reduced by over 60% in immuno-precipitates from HEK293 cells exposed to high urea concentration. Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.44 KCl in vitro: no direct decrease in GDPD5 activity, measuring choline by chemiluminescence, substrate sn-glycero-3-phosphocholine Mus musculus
3.1.4.44 NaCl in vivo: activity decreases (mIMCD-3 cell), measuring choline by chemiluminescence, substrate sn-glycero-3-phosphocholine. in vitro: no direct decrease in GDPD5 activity, GPC-PDE in vitro activity is reduced by over 60% in immuno-precipitates from HEK293 cells exposed to high NaCl concentration. Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.44 Mus musculus Q640M6
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-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.44 IMCD-3 cell
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Mus musculus
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Synonyms

EC Number Synonyms Comment Organism
3.1.4.44 glycerophosphodiester phosphodiesterase domain containing 5 GDPD5, BC024955 Mus musculus