Literature summary extracted from

Jiang, L.; Wang, M.; Zhang, J.; Monticone, R.E.; Telljohann, R.; Spinetti, G.; Pintus, G.; Lakatta, E.G.
Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells (2008), PLoS ONE, 3, e2231.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.22.52	angiotensin II	1.2-fold increased activity of calpain-1, influence in expression of calpain-1	Rattus norvegicus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.22.52	inhibitor protein Ci1	non-specific inhibitor	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.52	Rattus norvegicus	-	Fisher 344 x Brown Norway, male, 8-month old or 30-month old	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.22.52	aortic endothelial cell	-	Rattus norvegicus	-
3.4.22.52	vascular smooth muscle	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.22.52	alpha-II-spectrin + H2O	-	Rattus norvegicus	?	calpain-specific spectrin cleaved products	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.22.52	calpain-1	-	Rattus norvegicus

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Release 2023.1 (January 2023)