Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Rousar, T.; Parik, P.; Kucera, O.; Bartos, M.; Cervinkova, Z.
    Glutathione reductase is inhibited by acetaminophen-glutathione conjugate in vitro (2010), Physiol. Res., 59, 225-232.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 acetaminophen-glutathione conjugate the enzyme activity is inhibited to 48.1% after treatment with 2.96 mM acetaminophen-glutathione conjugate, the enzyme activity (from hepatocytes lysate) is decreased to 79%, 67%, and 397%, in 0.37, 1.48 and 3.7 mM concentration of the conjugate, respectively, at pH 7.6 at 25°C Rattus norvegicus
1.8.1.7 acetaminophen-glutathione conjugate the enzyme activity is inhibited to 52.7% after treatment with 2.96 mM acetaminophen-glutathione conjugate, at pH 7.6 at 25°C Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Rattus norvegicus
-
-
-
1.8.1.7 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 erythrocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+
-
 Rattus norvegicus glutathione + NADP+
-
 ?
1.8.1.7 glutathione disulfide + NADPH + H+
-
 Saccharomyces cerevisiae glutathione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 glutathione reductase
-
 Rattus norvegicus
1.8.1.7 glutathione reductase
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 FAD
-
 Rattus norvegicus
1.8.1.7 FAD
-
 Saccharomyces cerevisiae
1.8.1.7 NADPH
-
 Rattus norvegicus
1.8.1.7 NADPH
-
 Saccharomyces cerevisiae