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Literature summary extracted from

  • Stathopoulou, P.G.; Benakanakere, M.R.; Galicia, J.C.; Kinane, D.F.
    The host cytokine response to Porphyromonas gingivalis is modified by gingipains (2009), Oral Microbiol. Immunol., 24, 11-17.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.37 additional information gingipain-deficient Porphyromonas gingivalis mutants lacking both Arg- and Lys-gingipains are unable to induce interleukin-1beta, interleukin-6, and interleukin-8 degradation Porphyromonas gingivalis
3.4.22.47 additional information gingipain-deficient Porphyromonas gingivalis mutants lacking both Arg- and Lys-gingipains are unable to induce interleukin-1beta, interleukin-6, and interleukin-8 degradation Porphyromonas gingivalis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.37 leupeptin a specific arginine-gingipain inhibitor Porphyromonas gingivalis
3.4.22.47 Nalpha-benzoyl-Phe-Lys-chloromethyl ketone a specific inhibitor of lysine gingipain Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.37 interleukin-1beta + H2O Porphyromonas gingivalis biological inactivation and degradation, low activity, cytokine degradation is mainly the result of Lys-gingipain, EC 3.4.22.47 ?
-
 ?
3.4.22.37 interleukin-6 + H2O Porphyromonas gingivalis biological inactivation and degradation ?
-
 ?
3.4.22.37 interleukin-8 + H2O Porphyromonas gingivalis biological inactivation and degradation ?
-
 ?
3.4.22.37 additional information Porphyromonas gingivalis extracellular gingipain protease activities cause a lack of secondary cytokine response in human cells after challenge with live Porphyromonas gingivalis ?
-
 ?
3.4.22.47 interleukin-1beta + H2O Porphyromonas gingivalis biological inactivation and degradation, low activity, cytokine degradation is mainly the result of Lys-gingipain ?
-
 ?
3.4.22.47 interleukin-6 + H2O Porphyromonas gingivalis biological inactivation and degradation ?
-
 ?
3.4.22.47 interleukin-8 + H2O Porphyromonas gingivalis biological inactivation and degradation ?
-
 ?
3.4.22.47 additional information Porphyromonas gingivalis extracellular gingipain protease activities cause a lack of secondary cytokine response in human cells after challenge with live Porphyromonas gingivalis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.37 Porphyromonas gingivalis
-
 strains ATCC33277 and W50/ATCC 53978
-
3.4.22.47 Porphyromonas gingivalis
-
 strains ATCC33277 and W50/ATCC 53978
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.37 interleukin-1beta + H2O low activity Porphyromonas gingivalis ?
-
 ?
3.4.22.37 interleukin-1beta + H2O biological inactivation and degradation, low activity, cytokine degradation is mainly the result of Lys-gingipain, EC 3.4.22.47 Porphyromonas gingivalis ?
-
 ?
3.4.22.37 interleukin-6 + H2O
-
 Porphyromonas gingivalis ?
-
 ?
3.4.22.37 interleukin-6 + H2O biological inactivation and degradation Porphyromonas gingivalis ?
-
 ?
3.4.22.37 interleukin-8 + H2O
-
 Porphyromonas gingivalis ?
-
 ?
3.4.22.37 interleukin-8 + H2O biological inactivation and degradation Porphyromonas gingivalis ?
-
 ?
3.4.22.37 additional information extracellular gingipain protease activities cause a lack of secondary cytokine response in human cells after challenge with live Porphyromonas gingivalis Porphyromonas gingivalis ?
-
 ?
3.4.22.37 N-alpha-benzoyl-DL-arginine-4-nitroanilide + H2O
-
 Porphyromonas gingivalis N-alpha-benzoyl-DL-arginine + 4-nitroaniline
-
 ?
3.4.22.47 acetyl-lysine-4-nitroanilide + H2O
-
 Porphyromonas gingivalis acetyl-lysine + 4-nitroaniline
-
 ?
3.4.22.47 interleukin-1beta + H2O low activity Porphyromonas gingivalis ?
-
 ?
3.4.22.47 interleukin-1beta + H2O biological inactivation and degradation, low activity, cytokine degradation is mainly the result of Lys-gingipain Porphyromonas gingivalis ?
-
 ?
3.4.22.47 interleukin-6 + H2O
-
 Porphyromonas gingivalis ?
-
 ?
3.4.22.47 interleukin-6 + H2O biological inactivation and degradation Porphyromonas gingivalis ?
-
 ?
3.4.22.47 interleukin-8 + H2O
-
 Porphyromonas gingivalis ?
-
 ?
3.4.22.47 interleukin-8 + H2O biological inactivation and degradation Porphyromonas gingivalis ?
-
 ?
3.4.22.47 additional information extracellular gingipain protease activities cause a lack of secondary cytokine response in human cells after challenge with live Porphyromonas gingivalis Porphyromonas gingivalis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.37 Arg-gingipain
-
 Porphyromonas gingivalis
3.4.22.37 arginine-gingipain
-
 Porphyromonas gingivalis
3.4.22.37 RGP
-
 Porphyromonas gingivalis
3.4.22.37 RgpA
-
 Porphyromonas gingivalis
3.4.22.37 RgpB
-
 Porphyromonas gingivalis
3.4.22.47 KGP
-
 Porphyromonas gingivalis
3.4.22.47 Lys-gingipain
-
 Porphyromonas gingivalis
3.4.22.47 lysine gingipain
-
 Porphyromonas gingivalis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.37 37
-
 assay at Porphyromonas gingivalis
3.4.22.47 37
-
 assay at Porphyromonas gingivalis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.37 7.4
-
 assay at Porphyromonas gingivalis
3.4.22.47 7.4
-
 assay at Porphyromonas gingivalis