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Literature summary extracted from

  • Terebiznik, M.R.; Vieira, O.V.; Marcus, S.L.; Slade, A.; Yip, C.M.; Trimble, W.S.; Meyer, T.; Finlay, B.B.; Grinstein, S.
    Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella (2002), Nat. Cell Biol., 4, 766-773.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.78 Salmonella typhimurium SL1344 wild-type and deltaSigD mutant lacking SigD. Transfection of COS-7 and HeLa cells with SigD in mammalian expression vectors. Visualization of phosphatidylinositol 4,5-bisphosphate during Salmonella infection. Fusion protein of PH domain of phospholipase Cdelta and GFP (PLCdelta-PH-GFP) during invasion of HeLA cells by Salmonella (confocal fluorescence microscopy): phosphatidylinositol 4,5-bisphosphate is abundant near the tip but disappears from the basal regions. Role of SigD in phosphatidylinositol 4,5-bisphosphate elimination: focal disappearance of phosphatidylinositol 4,5-bisphosphate observed during invasion (wild-type) is diminished and delayed in the deltaSigD mutant (confocal fluorescence microscopy). SigD alters memebrane elasticity (atomic force microscopy, SigD transfected HeLa cells) and induces vacuole formation. SigD promotes membrane fission during invasion (SigD transfected HeLa cells) Salmonella enterica subsp. enterica serovar Typhimurium

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.78 C462S does not restore the ability of Salmonella to eliminate phosphatidylinositol 4,5-bisphosphate in SigD-deficient bacteria Salmonella enterica subsp. enterica serovar Typhimurium
3.1.3.78 K527A restores the ability of Salmonella to eliminate phosphatidylinositol 4,5-bisphosphate in SigD-deficient bacteria Salmonella enterica subsp. enterica serovar Typhimurium
3.1.3.78 K530A restores the ability of Salmonella to eliminate phosphatidylinositol 4,5-bisphosphate in SigD-deficient bacteria Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.78 phosphatidylinositol 3,4,5-trisphosphate + H2O Salmonella enterica subsp. enterica serovar Typhimurium
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phosphatidylinositol 3,5-bisphosphate + phosphate
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Organism

EC Number Organism UniProt Comment Textmining
3.1.3.78 Salmonella enterica subsp. enterica serovar Typhimurium O30916
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.78 phosphatidylinositol 3,4,5-trisphosphate + H2O
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Salmonella enterica subsp. enterica serovar Typhimurium phosphatidylinositol 3,5-bisphosphate + phosphate
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Synonyms

EC Number Synonyms Comment Organism
3.1.3.78 SigD
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Salmonella enterica subsp. enterica serovar Typhimurium