Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Day, J.M.; Tutill, H.J.; Foster, P.A.; Bailey, H.V.; Heaton, W.B.; Sharland, C.M.; Vicker, N.; Potter, B.V.; Purohit, A.; Reed, M.J.
    Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (2009), Mol. Cell. Endocrinol., 301, 251-258.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.64 expressed in LNCaP cells and in an 293-EBNA-based cell line Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.64 STX-2171
-
 Homo sapiens
1.1.1.64 STX-2622
-
 Homo sapiens
1.1.1.64 STX-2624
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.64 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.64 prostate cancer cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.64 androst-4-ene-3,17-dione + NADPH + H+
-
 Homo sapiens testosterone + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.64 17beta-HSD3
-
 Homo sapiens
1.1.1.64 17beta-hydroxysteroid dehydrogenase type 3
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.64 NADPH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.64 0.000201
-
 at 37°C Homo sapiens STX-2622
1.1.1.64 0.000383
-
 at 37°C Homo sapiens STX-2171
1.1.1.64 0.000441
-
 at 37°C Homo sapiens STX-2624