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Literature summary extracted from

  • Greetham, D.; Grant, C.M.
    Antioxidant activity of the yeast mitochondrial one-Cys peroxiredoxin is dependent on thioredoxin reductase and glutathione in vivo (2009), Mol. Cell. Biol., 29, 3229-3240.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.1.9 mitochondrion
-
 Saccharomyces cerevisiae 5739
-
1.11.1.27 mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.11.1.27 60000
-
 SDS-PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.9 thioredoxin disulfide + NADPH + H+ Saccharomyces cerevisiae
-
 thioredoxin + NADP+
-
 ?
1.11.1.27 additional information Saccharomyces cerevisiae Prx1 is particularly required to protect against mitochondrial oxidation, Prx1 requires thioredoxin reductase 2 and the glutathione system, but not thioredoxin 3, to promote oxidant resistance ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Saccharomyces cerevisiae
-
-
-
1.11.1.27 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.1.9 Ni-NTA His Bind resin column chromatography Saccharomyces cerevisiae
1.11.1.27 Ni-NTA His bind resin column chromatography, gel filtration Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
 Saccharomyces cerevisiae thioredoxin + NADP+
-
 ?
1.11.1.27 H2O2 + GSH
-
 Saccharomyces cerevisiae H2O + GSSG
-
 ?
1.11.1.27 additional information Prx1 is particularly required to protect against mitochondrial oxidation, Prx1 requires thioredoxin reductase 2 and the glutathione system, but not thioredoxin 3, to promote oxidant resistance Saccharomyces cerevisiae ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase
-
 Saccharomyces cerevisiae
1.8.1.9 TRR2
-
 Saccharomyces cerevisiae
1.11.1.27 Prx1 a 1-Cys peroxiredoxin Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 NADPH
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
1.8.1.9 physiological function Trr2/Trx3 and Trr2/GSH systems exhibit similar capacities for supporting peroxidredoxin 1 catalysis. TRR2 is required for cadmium and hydrogen peroxide resistance promoted by overexpression of peroxiredoxin 1 Saccharomyces cerevisiae