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Literature summary extracted from

  • Muthusamy, B.P.; Raychaudhuri, S.; Natarajan, P.; Abe, F.; Liu, K.; Prinz, W.A.; Graham, T.R.
    Control of protein and sterol trafficking by antagonistic activities of a P4-ATPase and oxysterol binding protein homologue (2009), Mol. Biol. Cell, 20, 2920-2931.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
7.6.2.1 additional information Drs2p deficiency causes a markedly increased rate of cholesterol transport from the plasma membrane to the endoplasmic reticulum and redistribution of endogenous ergosterol to intracellular membranes Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.1 Kes1p Kes1p represses the flippase activity of Drs2p in trans-Golgi network membranes Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.1 membrane trans-Golgi network membranes Saccharomyces cerevisiae 16020
-

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.1 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.1 ATP + H2O + phosphatidylethanolamine/out
-
 Saccharomyces cerevisiae ADP + phosphate + phosphatidylethanolamine/in
-
 ?
7.6.2.1 ATP + H2O + phosphatidylserine/out
-
 Saccharomyces cerevisiae ADP + phosphate + phosphatidylserine/in
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.1 Drs2-dependent phosphatidylserine translocase
-
 Saccharomyces cerevisiae
7.6.2.1 Drs2p
-
 Saccharomyces cerevisiae
7.6.2.1 flippase
-
 Saccharomyces cerevisiae
7.6.2.1 P4-ATPase
-
 Saccharomyces cerevisiae
7.6.2.1 type IV P-type ATPase
-
 Saccharomyces cerevisiae