BRENDA - Enzyme Database

Control of protein and sterol trafficking by antagonistic activities of a P4-ATPase and oxysterol binding protein homologue

Muthusamy, B.P.; Raychaudhuri, S.; Natarajan, P.; Abe, F.; Liu, K.; Prinz, W.A.; Graham, T.R.; Mol. Biol. Cell 20, 2920-2931 (2009)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
7.6.2.1
additional information
Drs2p deficiency causes a markedly increased rate of cholesterol transport from the plasma membrane to the endoplasmic reticulum and redistribution of endogenous ergosterol to intracellular membranes
Saccharomyces cerevisiae
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
7.6.2.1
Kes1p
Kes1p represses the flippase activity of Drs2p in trans-Golgi network membranes
Saccharomyces cerevisiae
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
7.6.2.1
membrane
trans-Golgi network membranes
Saccharomyces cerevisiae
16020
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
7.6.2.1
Saccharomyces cerevisiae
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
7.6.2.1
ATP + H2O + phosphatidylethanolamine/out
-
700100
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylethanolamine/in
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/out
-
700100
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylserine/in
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
7.6.2.1
additional information
Drs2p deficiency causes a markedly increased rate of cholesterol transport from the plasma membrane to the endoplasmic reticulum and redistribution of endogenous ergosterol to intracellular membranes
Saccharomyces cerevisiae
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
7.6.2.1
Kes1p
Kes1p represses the flippase activity of Drs2p in trans-Golgi network membranes
Saccharomyces cerevisiae
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
7.6.2.1
membrane
trans-Golgi network membranes
Saccharomyces cerevisiae
16020
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
7.6.2.1
ATP + H2O + phosphatidylethanolamine/out
-
700100
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylethanolamine/in
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/out
-
700100
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylserine/in
-
-
-
?