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Literature summary extracted from

  • Franco, J.L.; Posser, T.; Mattos, J.J.; Sanchez-Chardi, A.; Trevisan, R.; Oliveira, C.S.; Carvalho, P.S.; Leal, R.B.; Marques, M.R.; Bainy, A.C.; Dafre, A.L.
    Biochemical alterations in juvenile carp (Cyprinus carpio) exposed to zinc: glutathione reductase as a target (2008), Mar. Environ. Res., 66, 88-89.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 Zn2+
-
 Cyprinus carpio

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Cyprinus carpio
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 brain
-
 Cyprinus carpio
-
1.8.1.7 gill
-
 Cyprinus carpio
-
1.8.1.7 liver
-
 Cyprinus carpio
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+
-
 Cyprinus carpio glutathione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 glutathione reductase
-
 Cyprinus carpio

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 NADPH
-
 Cyprinus carpio

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.7 0.007
-
-
 Cyprinus carpio Zn2+

Expression

EC Number Organism Comment Expression
1.8.1.7 Cyprinus carpio zinc exposure (0.01, 0.03, and 0.1 mM Zn2+ for a period of 48 h) causes a concentration-dependent reduction in glutathione reductase activity in gills, liver and brain down