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Literature summary extracted from

  • Hu, G.X.; Zhou, H.Y.; Li, X.W.; Chen, B.B.; Xiao, Y.C.; Lian, Q.Q.; Liang, G.; Kim, H.H.; Zheng, Z.Q.; Hardy, D.O.; Ge, R.S.
    The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes (2009), J. Steroid Biochem. Mol. Biol., 115, 14-19.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.64 (+)-gossypol
-
Homo sapiens
1.1.1.64 (+)-gossypol
-
Rattus norvegicus
1.1.1.64 (-)-gossypol
-
Homo sapiens
1.1.1.64 (-)-gossypol
-
Rattus norvegicus
1.1.1.145 (+)-gossypol potent inhibitor Homo sapiens
1.1.1.145 (+)-gossypol potent inhibitor Rattus norvegicus
1.1.1.145 (-)-gossypol potent inhibitor Homo sapiens
1.1.1.145 (-)-gossypol potent inhibitor Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.64 microsome
-
Homo sapiens
-
-
1.1.1.64 microsome
-
Rattus norvegicus
-
-
1.1.1.145 microsome
-
Homo sapiens
-
-
1.1.1.145 microsome
-
Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.64 Homo sapiens
-
-
-
1.1.1.64 Rattus norvegicus
-
-
-
1.1.1.145 Homo sapiens
-
-
-
1.1.1.145 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.64 testis
-
Homo sapiens
-
1.1.1.64 testis
-
Rattus norvegicus
-
1.1.1.145 testis
-
Homo sapiens
-
1.1.1.145 testis
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.64 androstenedione + NADPH + H+ 17beta-HSD3 Homo sapiens testosterone + NADP+
-
?
1.1.1.64 androstenedione + NADPH + H+ 17beta-HSD3 Rattus norvegicus testosterone + NADP+
-
?
1.1.1.145 pregnenolone + NAD+
-
Homo sapiens progesterone + NADH + H+
-
?
1.1.1.145 pregnenolone + NAD+
-
Rattus norvegicus progesterone + NADH + H+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.64 17beta-HSD3
-
Homo sapiens
1.1.1.64 17beta-HSD3
-
Rattus norvegicus
1.1.1.64 17beta-hydroxysteroid dehydrogenase 3
-
Homo sapiens
1.1.1.64 17beta-hydroxysteroid dehydrogenase 3
-
Rattus norvegicus
1.1.1.145 3beta-HSD
-
Homo sapiens
1.1.1.145 3beta-HSD
-
Rattus norvegicus
1.1.1.145 3beta-hydroxysteroid dehydrogenase
-
Homo sapiens
1.1.1.145 3beta-hydroxysteroid dehydrogenase
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.64 NADPH
-
Homo sapiens
1.1.1.64 NADPH
-
Rattus norvegicus
1.1.1.145 NAD+
-
Homo sapiens
1.1.1.145 NAD+
-
Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.64 0.00036
-
in PBS buffer, pH 7.2 Homo sapiens (-)-gossypol
1.1.1.64 0.00113
-
in PBS buffer, pH 7.2 Homo sapiens (+)-gossypol
1.1.1.64 0.00343
-
in PBS buffer, pH 7.2 Rattus norvegicus (-)-gossypol
1.1.1.64 0.01093
-
in PBS buffer, pH 7.2 Rattus norvegicus (+)-gossypol
1.1.1.145 0.00019
-
in PBS buffer, pH 7.2 Rattus norvegicus (+)-gossypol
1.1.1.145 0.00023
-
in PBS buffer, pH 7.2 Rattus norvegicus (-)-gossypol
1.1.1.145 0.00277
-
in PBS buffer, pH 7.2 Homo sapiens (-)-gossypol
1.1.1.145 0.00445
-
in PBS buffer, pH 7.2 Homo sapiens (+)-gossypol