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Literature summary extracted from

  • Nakashima, A.; Hayashi, N.; Kaneko, Y.S.; Mori, K.; Sabban, E.L.; Nagatsu, T.; Ota, A.
    Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines (2009), J. Neural Transm., 116, 1355-1362.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.16.2 expressed in monkey striatum using harmless adeno-associated virus vectors and in PC-12 cells and AtT-20 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.16.2 additional information the deletion mutation of N-terminal 38-amino acids increases the binding capacity of 5,6,7,8,-tetrahydrobiopterin to tyrosine hydroxylase molecule to increase the activity and possibly to increase the stability Homo sapiens
1.14.16.2 R37E/R38E the point mutation increases the binding capacity of 5,6,7,8,-tetrahydrobiopterin to tyrosine hydroxylase molecule to increase the activity and possibly to increase the stability Homo sapiens

General Stability

EC Number General Stability Organism
1.14.16.2 the 14-3-3eta protein regulates tyrosine hydroxylase type 1 stability against degradation by acting on the N-terminus Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.2 adrenaline
-
 Homo sapiens
1.14.16.2 dopamine
-
 Homo sapiens
1.14.16.2 noradrenaline
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.2 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.14.16.2 phosphoprotein Ser31 and Ser40 are readily phosphorylated to activate tyrosine hydroxylase type 1 in vitro. Although phosphorylation of Ser19 does not directly activate tyrosine hydroxylase, chaperone 14-3-3 protein binds and activates tyrosine hydroxylase at Ser19 phosphorylated by Ca2+/calmodulin-dependent protein kinase II. Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.2 L-tyrosine + 5,6,7,8-tetrahydro-L-biopterin + O2
-
 Homo sapiens 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydro-L-biopterin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.16.2 TH1 isoform Homo sapiens
1.14.16.2 tyrosine hydroxylase
-
 Homo sapiens
1.14.16.2 tyrosine hydroxylase type 1 isoform Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.16.2 5,6,7,8-tetrahydro-L-biopterin
-
 Homo sapiens