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Literature summary extracted from

  • Ono, K.; Shishido, Y.; Park, H.K.; Kawazoe, T.; Iwana, S.; Chung, S.P.; Abou El-Magd, R.M.; Yorita, K.; Okano, M.; Watanabe, T.; Sano, N.; Bando, Y.; Arima, K.; Sakai, T.; Fukui, K.
    Potential pathophysiological role of D-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain (2009), J. Neural Transm., 116, 1335-1347.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.4.3.3 drug development the enzyme is a potential therapeutic target for schizophrenia treatment Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.3 peroxisome
-
 Homo sapiens 5777
-
1.4.3.3 peroxisome
-
 Rattus norvegicus 5777
-

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Homo sapiens
-
-
-
1.4.3.3 Rattus norvegicus O35078
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.4.3.3 flavoprotein
-
 Homo sapiens
1.4.3.3 flavoprotein
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 brain in choroid plexus epithelial cells and glial cells of rhombencephalon. Higher level of DAO expression is observed in schizophrenic choroid plexus epithelial cells than that in non-schizophrenic cases Homo sapiens
-
1.4.3.3 brain in choroid plexus epithelial cells, glial cells of pons, medulla oblongata, and especially in Bergmann glia of cerebellum Rattus norvegicus
-
1.4.3.3 cerebellum Bermann glia Rattus norvegicus
-
1.4.3.3 additional information in situ hybridization and immunohistochemic determination Homo sapiens
-
1.4.3.3 additional information in situ hybridization and immunohistochemic determination Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 additional information D-amino acid oxidase is a flavoenzyme that catalyzes the oxidation of D-amino acids to the corresponding imino acids and hydrogen peroxide Homo sapiens ?
-
 ?
1.4.3.3 additional information D-amino acid oxidase is a flavoenzyme that catalyzes the oxidation of D-amino acids to the corresponding imino acids and hydrogen peroxide Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 DAO
-
 Homo sapiens
1.4.3.3 DAO
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.3 flavin flavoenzyme Homo sapiens
1.4.3.3 flavin flavoenzyme Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.4.3.3 Homo sapiens higher level of DAO expression is observed in schizophrenic choroid plexus epithelial cells than that in non-schizophrenic cases up

General Information

EC Number General Information Comment Organism
1.4.3.3 malfunction an increase in DAO expression in parts of the brain is involved in aberrant D-amino acid metabolism Homo sapiens
1.4.3.3 physiological function DAO may regulate D-amino acid concentration by modulating the cerebrospinal fluid Homo sapiens