EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.7 | 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium | - |
Homo sapiens | |
1.8.1.7 | N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine | - |
Homo sapiens | |
1.8.1.7 | N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine | - |
Homo sapiens | |
1.8.1.7 | N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-aminium | - |
Homo sapiens | |
1.8.1.7 | N,N-dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-aminium | - |
Homo sapiens | |
1.8.1.12 | (1E)-1-[2-chloro-10-[3-(dimethylamino)propyl]-10,10a-dihydro-4aH-phenothiazin-8-yl]ethanone O-benzyloxime | - |
Trypanosoma cruzi | |
1.8.1.12 | 1,1'-(10-acetyl-10,10a-dihydro-4aH-phenothiazine-2,8-diyl)diethanone | - |
Trypanosoma cruzi | |
1.8.1.12 | 1,1'-[10-[3-(dimethylamino)propyl]-10,10a-dihydro-4aH-phenothiazine-2,8-diyl]diethanone | - |
Trypanosoma cruzi | |
1.8.1.12 | 1-(10-acetyl-10,10a-dihydro-4aH-phenothiazin-2-yl)-2-chloroethanone | - |
Trypanosoma cruzi | |
1.8.1.12 | 1-(10-acetyl-10,10a-dihydro-4aH-phenothiazin-2-yl)ethanone | - |
Trypanosoma cruzi | |
1.8.1.12 | 1-(10-acetyl-2-chloro-10,10a-dihydro-4aH-phenothiazin-8-yl)ethanone | - |
Trypanosoma cruzi | |
1.8.1.12 | 1-(4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-2-amine | - |
Trypanosoma cruzi | |
1.8.1.12 | 1-(4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-2-amine | - |
Trypanosoma cruzi | |
1.8.1.12 | 1-[2-chloro-10-[3-(dimethylamino)propyl]-10,10a-dihydro-4aH-phenothiazin-8-yl]ethanone | - |
Trypanosoma cruzi | |
1.8.1.12 | 10-(bromoacetyl)-2-chloro-10,10a-dihydro-4aH-phenothiazine | - |
Trypanosoma cruzi | |
1.8.1.12 | 10-butanoyl-2-chloro-10,10a-dihydro-4aH-phenothiazine | - |
Trypanosoma cruzi | |
1.8.1.12 | 10-[3-(4-methylpiperidin-1-yl)propyl]-2-(trifluoromethyl)-10,10a-dihydro-4aH-phenothiazine | - |
Trypanosoma cruzi | |
1.8.1.12 | 10H-phenothiazine | - |
Trypanosoma cruzi | |
1.8.1.12 | 2-(1-[3-[2-(trifluoromethyl)-4a,10a-dihydro-10H-phenothiazin-10-yl]propyl]piperidin-4-yl)ethanol | - |
Trypanosoma cruzi | |
1.8.1.12 | 2-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-diethyl-2-oxoethanamine | - |
Trypanosoma cruzi | |
1.8.1.12 | 2-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-diethylethanamine | - |
Trypanosoma cruzi | |
1.8.1.12 | 2-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-dimethylethanamine | - |
Trypanosoma cruzi | |
1.8.1.12 | 2-(4a,10a-dihydro-10H-phenothiazin-10-yl)-N-methylethanamine | - |
Trypanosoma cruzi | |
1.8.1.12 | 2-chloro-10-(chloroacetyl)-10,10a-dihydro-4aH-phenothiazine | - |
Trypanosoma cruzi | |
1.8.1.12 | 2-chloro-10-[3-[(Z)-propyldiazenyl]propyl]-10,10a-dihydro-4aH-phenothiazine | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(2-acetyl-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(2-butanoyl-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(2-carbamoyl-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(2-carboxy-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-diethyl-3-oxopropan-1-amine | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-diethylpropan-1-amine | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N-methylpropan-1-amine | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)propan-1-amine | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)propanimidamide | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(2-chloro-5-oxido-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(2-hexanoyl-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(4-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(4a,10a-dihydro-10H-phenothiazin-10-yl)propan-1-amine | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-(4a,10a-dihydro-10H-phenothiazin-10-yl)propanimidamide | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-[2-(aminomethyl)-10H-phenothiazin-10-yl]-N,N-dimethylpropan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-[2-(hydroxymethyl)-10H-phenothiazin-10-yl]-N,N-dimethylpropan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-[2-(methoxycarbonyl)-10H-phenothiazin-10-yl]-N,N-dimethylpropan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-[2-[(1E)-N-benzyl-N-oxidoethanimidoyl]-10H-phenothiazin-10-yl]-N,N-dimethylpropan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | 3-[2-[(E)-(hydroxyimino)methyl]-10H-phenothiazin-10-yl]-N,N-dimethylpropan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | 4-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-4-oxo-N'-phenylbutanehydrazide | - |
Trypanosoma cruzi | |
1.8.1.12 | 4-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-4-oxobutanoic acid | - |
Trypanosoma cruzi | |
1.8.1.12 | 4-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-diethyl-4-oxobutan-1-amine | - |
Trypanosoma cruzi | |
1.8.1.12 | 6-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-diethyl-6-oxohexan-1-amine | - |
Trypanosoma cruzi | |
1.8.1.12 | N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | N,N-dimethyl-3-(2-propanoyl-10H-phenothiazin-10-yl)propan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | N,N-dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | N,N-dimethyl-3-[2-[(1E)-N-methyl-N-oxidoethanimidoyl]-10H-phenothiazin-10-yl]propan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | N-benzyl-4-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-4-oxobutanamide | - |
Trypanosoma cruzi | |
1.8.1.12 | N-[2-(2-chloro-4a,10a-dihydro-10H-phenothiazin-10-yl)-2-oxoethyl]aniline | - |
Trypanosoma cruzi |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.7 | glutathione disulfide + NADPH + H+ | Homo sapiens | - |
glutathione + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.1.7 | Homo sapiens | P00390 | - |
- |
1.8.1.12 | Trypanosoma cruzi | P28593 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.8.1.7 | erythrocyte | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.7 | glutathione disulfide + NADPH + H+ | - |
Homo sapiens | glutathione + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.8.1.7 | glutathione reductase | - |
Homo sapiens |
1.8.1.12 | trypanothione reductase | - |
Trypanosoma cruzi |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.7 | FAD | - |
Homo sapiens | |
1.8.1.7 | NADPH | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.8.1.12 | 0.0108 | - |
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | 0.0187 | - |
2-chloro-10-[3-[(Z)-propyldiazenyl]propyl]-10,10a-dihydro-4aH-phenothiazine | - |
Trypanosoma cruzi | |
1.8.1.12 | 0.0212 | - |
2-(1-[3-[2-(trifluoromethyl)-4a,10a-dihydro-10H-phenothiazin-10-yl]propyl]piperidin-4-yl)ethanol | - |
Trypanosoma cruzi | |
1.8.1.12 | 0.023 | - |
10-[3-(4-methylpiperidin-1-yl)propyl]-2-(trifluoromethyl)-10,10a-dihydro-4aH-phenothiazine | - |
Trypanosoma cruzi | |
1.8.1.12 | 0.0302 | - |
N,N-dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | 0.0591 | - |
N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-aminium | - |
Trypanosoma cruzi | |
1.8.1.12 | 0.127 | - |
3-(4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine | - |
Trypanosoma cruzi | |
1.8.1.12 | 0.216 | - |
1-(4a,10a-dihydro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-2-amine | - |
Trypanosoma cruzi |