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Literature summary extracted from

  • Maiti, A.; Reddy, P.V.; Sturdy, M.; Marler, L.; Pegan, S.D.; Mesecar, A.D.; Pezzuto, J.M.; Cushman, M.
    Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities (2009), J. Med. Chem., 52, 1873-1884.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.10.5.1 X-ray crystallography studies of QR2 in complex with 6-methoxy-9-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.5.1 1,4-dimethylquinolin-2(1H)-one
-
 Homo sapiens
1.10.5.1 5,6,8-trimethoxy-1,4-dimethylquinolin-2(1H)-one
-
 Homo sapiens
1.10.5.1 5,6,8-trimethoxy-4-methylquinolin-2(1H)-one
-
 Homo sapiens
1.10.5.1 5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
-
 Homo sapiens
1.10.5.1 5,8-dimethoxy-4-methylquinolin-2(1H)-one
-
 Homo sapiens
1.10.5.1 6,7,8-trimethoxy-1,4-dimethylquinolin-2(1H)-one
-
 Homo sapiens
1.10.5.1 6,7,8-trimethoxy-4-methylquinolin-2(1H)-one
-
 Homo sapiens
1.10.5.1 6,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
-
 Homo sapiens
1.10.5.1 6,8-dimethoxy-4-methylquinolin-2(1H)-one
-
 Homo sapiens
1.10.5.1 6,9-dimethyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one
-
 Homo sapiens
1.10.5.1 6-methoxy-9-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one
-
 Homo sapiens
1.10.5.1 6-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one
-
 Homo sapiens
1.10.5.1 7,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
-
 Homo sapiens
1.10.5.1 7,8-dimethoxy-4-methylquinolin-2(1H)-one
-
 Homo sapiens
1.10.5.1 8-methoxy-1,4-dimethylquinolin-2(1H)-one
-
 Homo sapiens
1.10.5.1 8-methoxy-4-methylquinolin-2(1H)-one
-
 Homo sapiens
1.10.5.1 Melatonin
-
 Homo sapiens
1.10.5.1 additional information no inhibition by 4-methylquinolin-2(1H)-one. 6-Methoxy-9-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one and its analogues merit further investigation as potential chemopreventive or chemotherapeutic agents Homo sapiens
1.10.5.1 resveratrol
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.10.5.1 Homo sapiens
-
 recombinant
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.10.5.1
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.10.5.1 QR2
-
 Homo sapiens
1.10.5.1 quinone reductase 2
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.10.5.1 0.00096
-
 23°C Homo sapiens resveratrol
1.10.5.1 0.0019
-
 23°C Homo sapiens 6,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
1.10.5.1 0.0041
-
 23°C Homo sapiens 5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
1.10.5.1 0.0058
-
 23°C Homo sapiens 8-methoxy-1,4-dimethylquinolin-2(1H)-one
1.10.5.1 0.006
-
 23°C Homo sapiens 5,6,8-trimethoxy-4-methylquinolin-2(1H)-one
1.10.5.1 0.0062
-
 23°C Homo sapiens 6,9-dimethyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one
1.10.5.1 0.007
-
 23°C Homo sapiens 6,7,8-trimethoxy-1,4-dimethylquinolin-2(1H)-one
1.10.5.1 0.0088
-
 23°C Homo sapiens 6,8-dimethoxy-4-methylquinolin-2(1H)-one
1.10.5.1 0.0093
-
 23°C Homo sapiens 7,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
1.10.5.1 0.01
-
 23°C Homo sapiens 6,7,8-trimethoxy-4-methylquinolin-2(1H)-one
1.10.5.1 0.0108
-
 23°C Homo sapiens 6-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one
1.10.5.1 0.0108
-
 23°C Homo sapiens 5,8-dimethoxy-4-methylquinolin-2(1H)-one
1.10.5.1 0.0108
-
 23°C Homo sapiens 5,6,8-trimethoxy-1,4-dimethylquinolin-2(1H)-one
1.10.5.1 0.0113
-
 23°C Homo sapiens Melatonin
1.10.5.1 0.0182
-
 23°C Homo sapiens 1,4-dimethylquinolin-2(1H)-one
1.10.5.1 0.0241
-
 23°C Homo sapiens 8-methoxy-4-methylquinolin-2(1H)-one
1.10.5.1 0.0293
-
 23°C Homo sapiens 7,8-dimethoxy-4-methylquinolin-2(1H)-one
1.10.5.1 0.0541
-
 23°C Homo sapiens 6-methoxy-9-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one