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Literature summary extracted from

  • Cherney, R.J.; Duan, J.J.; Voss, M.E.; Chen, L.; Wang, L.; Meyer,D.T.; Wasserman, Z.R.; Hardman, K.D.; Liu, R.Q.; Covington, M.B.; Qian, M.; Mandlekar, S.; Christ, D.; Trzaskos, J.M.; Newton, R.C.; Magolda, R.L.; Wexler, R.R.; Decicco, C.P.
    Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors (2003), J. Med. Chem., 46, 1811-1823.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.86 (2R)-N-hydroxy-2-(7-methoxy-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl)-3-methylbutanamide
-
Sus scrofa
3.4.24.86 methyl (5R)-5-{7-[(3,5-diethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl}-6-(hydroxyamino)-6-oxohexanoate
-
Sus scrofa
3.4.24.86 methyl (5R)-5-{7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl}-6-(hydroxyamino)-6-oxohexanoate human whole blood assay: 31% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-(6-methoxy-1,1-dioxo-3,4-dihydro-1H-1-benzo[1,2,4]thiadiazin-2-yl)propionamide
-
Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[2,3,4,5-tetrahydrobenzo[1,2,5-f]-thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(2,6-methylpyridyl-4-methyleneoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-propanamide human whole blood assay: 37% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(2-trifluromethylphenyl)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propylamide
-
Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(3,5-dichlorobenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide human whole blood assay: 12% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide human whole blood assay: 17% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methoxycarbonylbutanamide human whole blood assay: 0% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide human whole blood assay: 26% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine 1,1-dioxide]-6-N-(methanesulfonyl)hexylamide
-
Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide human whole blood assay: 11% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methoxycarbonylbutanamide human whole blood assay: 0% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentanamide human whole blood assay: 16% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-6-aminohexylamidetrifluoroacetic acid salt human whole blood assay: 3% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-6-N-[(1,1-dimethylethoxy)carbonyl]hexylamide human whole blood assay: 3% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(3,5-dimethylbenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide human whole blood assay: 2% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(3-nitrophenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(4,5-dimethylthiazolyl-2-methyleneoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide human whole blood assay: 0% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(4-methoxyphenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(4-nitrophenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(4-phenylphenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(4-trifluoromethylphenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide human whole blood assay: 58% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-(N-3,5-dimethylbenzoylamino)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-propylamide
-
Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-benzyloxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentanamide human whole blood assay: 39% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-benzyloxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide human whole blood assay: 30% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-hydroxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentamide human whole blood assay: 20% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-hydroxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide human whole blood assay: 21% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-methoxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-N-(3,5-dimethoxymethyleneamino)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentamide human whole blood assay: 3% inhibition Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-phenoxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 N-hydroxy-2(R)-[7-phenyl-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propylamide
-
Sus scrofa
3.4.24.86 N-hydroxy-2-[2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]ethanamide
-
Sus scrofa
3.4.24.86 N-hydroxy-2-[7-methoxy-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]ethanamide
-
Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Sus scrofa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 additional information compounds are assessed in two cellular assays, the human peripheral blood mononuclear cell assay (PBMC) and the human whole blood assay (WBA), for their ability to suppress the formation of TNF-alpha brought about by lipopolysaccharide (LPS) stimulation. Success in the PBMC assay relies on the ability of the inhibitor to penetrate into the cells, thus enabling it to inhibit TACE and thereby to suppress the release of intracellular, soluble TNF-alpha. In the WBA, compounds must also have the ability to penetrate cells Sus scrofa ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.86 TACE
-
Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.24.86 0.000005
-
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine 1,1-dioxide]-6-N-(methanesulfonyl)hexylamide
-
Sus scrofa
3.4.24.86 0.00001
-
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide
-
Sus scrofa
3.4.24.86 0.00001
-
methyl (5R)-5-{7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl}-6-(hydroxyamino)-6-oxohexanoate
-
Sus scrofa
3.4.24.86 0.000011
-
N-hydroxy-2(R)-[7-(4-nitrophenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 0.000013
-
methyl (5R)-5-{7-[(3,5-diethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl}-6-(hydroxyamino)-6-oxohexanoate
-
Sus scrofa
3.4.24.86 0.000017
-
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentanamide
-
Sus scrofa
3.4.24.86 0.000027
-
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 0.000031
-
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-6-aminohexylamidetrifluoroacetic acid salt
-
Sus scrofa
3.4.24.86 0.000051
-
N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide
-
Sus scrofa
3.4.24.86 0.000056
-
N-hydroxy-2(R)-[7-N-(3,5-dimethoxymethyleneamino)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentamide
-
Sus scrofa
3.4.24.86 0.000071
-
(2R)-N-hydroxy-2-(7-methoxy-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl)-3-methylbutanamide
-
Sus scrofa
3.4.24.86 0.000077
-
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-6-N-[(1,1-dimethylethoxy)carbonyl]hexylamide
-
Sus scrofa
3.4.24.86 0.000081
-
N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 0.000089
-
N-hydroxy-2(R)-[7-hydroxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentamide
-
Sus scrofa
3.4.24.86 0.000129
-
N-hydroxy-2(R)-[7-(3-nitrophenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 0.000153
-
N-hydroxy-2(R)-[7-(3,5-dichlorobenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 0.000177
-
N-hydroxy-2(R)-[7-benzyloxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentanamide
-
Sus scrofa
3.4.24.86 0.000177
-
N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methoxycarbonylbutanamide
-
Sus scrofa
3.4.24.86 0.000229
-
N-hydroxy-2(R)-[7-(3,5-dimethylbenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 0.000242
-
N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methoxycarbonylbutanamide
-
Sus scrofa
3.4.24.86 0.000274
-
N-hydroxy-2(R)-[7-methoxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 0.00029
-
N-hydroxy-2(R)-[7-(4,5-dimethylthiazolyl-2-methyleneoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide
-
Sus scrofa
3.4.24.86 0.000391
-
N-hydroxy-2(R)-[7-hydroxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 0.000484
-
N-hydroxy-2(R)-[2,3,4,5-tetrahydrobenzo[1,2,5-f]-thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 0.000544
-
N-hydroxy-2(R)-[7-(2,6-methylpyridyl-4-methyleneoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-propanamide
-
Sus scrofa
3.4.24.86 0.000621
-
N-hydroxy-2(R)-[7-(4-methoxyphenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 0.000705
-
N-hydroxy-2(R)-[7-benzyloxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 0.000734
-
N-hydroxy-2(R)-[7-phenoxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 0.000758
-
N-hydroxy-2(R)-[7-(4-trifluoromethylphenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
-
Sus scrofa
3.4.24.86 0.001
-
N-hydroxy-2-[2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]ethanamide
-
Sus scrofa
3.4.24.86 0.001
-
N-hydroxy-2-[7-methoxy-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]ethanamide
-
Sus scrofa
3.4.24.86 0.001
-
N-hydroxy-2(R)-[7-(N-3,5-dimethylbenzoylamino)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-propylamide value above Sus scrofa
3.4.24.86 0.001
-
N-hydroxy-2(R)-[7-phenyl-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propylamide value above Sus scrofa
3.4.24.86 0.001
-
N-hydroxy-2(R)-[7-(2-trifluromethylphenyl)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propylamide value above Sus scrofa
3.4.24.86 0.001
-
N-hydroxy-2(R)-[7-(4-phenylphenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide value above Sus scrofa
3.4.24.86 0.0031
-
N-hydroxy-2(R)-(6-methoxy-1,1-dioxo-3,4-dihydro-1H-1-benzo[1,2,4]thiadiazin-2-yl)propionamide
-
Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.24.86 0.00035
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-benzyloxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentanamide
3.4.24.86 0.00047
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-(3-nitrophenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
3.4.24.86 0.00077
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
3.4.24.86 0.00084
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-(4-trifluoromethylphenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
3.4.24.86 0.0009
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa methyl (5R)-5-{7-[(3,5-dimethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl}-6-(hydroxyamino)-6-oxohexanoate
3.4.24.86 0.00094
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-(3,5-dichlorobenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
3.4.24.86 0.0011
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa methyl (5R)-5-{7-[(3,5-diethoxybenzyl)oxy]-1,1-dioxido-4,5-dihydro-1,2,5-benzothiadiazepin-2(3H)-yl}-6-(hydroxyamino)-6-oxohexanoate
3.4.24.86 0.0012
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-(4-nitrophenoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
3.4.24.86 0.0019
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine 1,1-dioxide]-6-N-(methanesulfonyl)hexylamide
3.4.24.86 0.0029
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-(2,6-methylpyridyl-4-methyleneoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-propanamide
3.4.24.86 0.004
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide
3.4.24.86 0.0045
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]propanamide
3.4.24.86 0.0054
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentanamide
3.4.24.86 0.0062
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methoxycarbonylbutanamide
3.4.24.86 0.0072
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-(3,5-dimethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methoxycarbonylbutanamide
3.4.24.86 0.0082
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-(3,5-diethoxybenzyloxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide
3.4.24.86 0.0095
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-hydroxy-2,3,4,5-tetrahydrobenzo-[1,2,5-f]thiadiazepine-1,1-dioxide]-4-methylpentamide
3.4.24.86 0.0245
-
human peripheral blood mononuclear cell assay (PBMC) Sus scrofa N-hydroxy-2(R)-[7-(4,5-dimethylthiazolyl-2-methyleneoxy)-2,3,4,5-tetrahydrobenzo[1,2,5-f]thiadiazepine-1,1-dioxide]-3-methylbutanamide