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Literature summary extracted from
- Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase (2009), J. Invest. Dermatol., 129, 2242-2249.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.18.1 | hydroquinone | - |
Agaricus bisporus |  |
| 1.14.18.1 | hydroquinone | - |
Homo sapiens | |
| 1.14.18.1 | KFEKKFEK | - |
Agaricus bisporus | |
| 1.14.18.1 | L-Pro-L-Leu-Gly | - |
Agaricus bisporus | |
| 1.14.18.1 | additional information | not inhibited by VLLK and KFEFKFEF | Agaricus bisporus | |
| 1.14.18.1 | RADSRADC | - |
Agaricus bisporus | |
| 1.14.18.1 | RADSRADC | 25% inhibition at 0.1 mM | Homo sapiens | |
| 1.14.18.1 | SFLLRN | - |
Agaricus bisporus | |
| 1.14.18.1 | YRSRKYSSWY | - |
Agaricus bisporus | |
| 1.14.18.1 | YRSRKYSSWY | 35% inhibition at 0.1 mM | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | Agaricus bisporus | - |
- |
- |
| 1.14.18.1 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | melanocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.18.1 | L-DOPA + O2 | - |
Homo sapiens | dopaquinone + H2O | - |
? | |
| 1.14.18.1 | L-DOPA + O2 | - |
Agaricus bisporus | dopaquinone + H2O | - |
? | |
| 1.14.18.1 | L-tyrosine + O2 | - |
Homo sapiens | L-DOPA + H2O | - |
? | |
| 1.14.18.1 | L-tyrosine + O2 | - |
Agaricus bisporus | L-DOPA + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | tyrosinase | - |
Homo sapiens |
| 1.14.18.1 | tyrosinase | - |
Agaricus bisporus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.14.18.1 | 0.04 | - |
in 0.67 mM potassium phosphate buffer (pH 6.8), at 37°C | Agaricus bisporus | YRSRKYSSWY | |
| 1.14.18.1 | 0.123 | - |
in 0.67 mM potassium phosphate buffer (pH 6.8), at 37°C | Agaricus bisporus | RADSRADC | |
| 1.14.18.1 | 2.73 | - |
in 0.67 mM potassium phosphate buffer (pH 6.8), at 37°C | Agaricus bisporus | L-Pro-L-Leu-Gly | |
| 1.14.18.1 | 3.6 | - |
in 0.67 mM potassium phosphate buffer (pH 6.8), at 37°C | Agaricus bisporus | KFEKKFEK | |
| 1.14.18.1 | 8 | - |
in 0.67 mM potassium phosphate buffer (pH 6.8), at 37°C | Agaricus bisporus | SFLLRN | |
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