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Literature summary extracted from
- Carbonic anhydrase inhibitors. Cloning, characterization and inhibition studies of the cytosolic isozyme III with anions (2009), J. Enzyme Inhib. Med. Chem., 24, 70-76.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.1 | azide | best inhibitor | Homo sapiens |  |
| 4.2.1.1 | bicarbonate | - |
Homo sapiens | |
| 4.2.1.1 | bromide | - |
Homo sapiens | |
| 4.2.1.1 | Carbonate | best inhibitor | Homo sapiens | |
| 4.2.1.1 | chloride | - |
Homo sapiens | |
| 4.2.1.1 | cyanide | best inhibitor | Homo sapiens | |
| 4.2.1.1 | fluoride | weak inhibitor | Homo sapiens | |
| 4.2.1.1 | hydrogen sulfide | best inhibitor | Homo sapiens | |
| 4.2.1.1 | hydrosulfide | - |
Homo sapiens | |
| 4.2.1.1 | nitrate | - |
Homo sapiens | |
| 4.2.1.1 | nitrite | - |
Homo sapiens | |
| 4.2.1.1 | phenylarsonic acid | weak inhibitor | Homo sapiens | |
| 4.2.1.1 | phenylboronic acid | weak inhibitor | Homo sapiens | |
| 4.2.1.1 | sulfamic acid | - |
Homo sapiens | |
| 4.2.1.1 | sulfamide | - |
Homo sapiens | |
| 4.2.1.1 | sulfate | - |
Homo sapiens | |
| 4.2.1.1 | thiocyanate | best inhibitor | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.2.1.1 | cytosol | - |
Homo sapiens | 5829 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.1 | Homo sapiens | P07451 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.1 | CO2 + H2O | - |
Homo sapiens | H2CO3 | - |
r | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.1.1 | CA I | isozyme | Homo sapiens |
| 4.2.1.1 | CA II | isozyme | Homo sapiens |
| 4.2.1.1 | CA III | isozyme | Homo sapiens |
| 4.2.1.1 | carbonic anhydrase isozyme III | - |
Homo sapiens |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.1 | 13000 | - |
CO2 | at 20°C and pH 7.5 | Homo sapiens | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.1 | 0.01 | - |
Carbonate | isozyme CA III | Homo sapiens | |
| 4.2.1.1 | 0.74 | - |
bicarbonate | isozyme CA III | Homo sapiens | |
| 4.2.1.1 | 12 | - |
bicarbonate | isozyme CA II | Homo sapiens | |
| 4.2.1.1 | 85 | - |
bicarbonate | isozyme CA I | Homo sapiens | |
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