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Literature summary extracted from

  • Senturk, M.; Kufrevioglu, O.I.; Ciftci, M.
    Effects of some antibiotics on human erythrocyte glutathione reductase: an in vitro study (2008), J. Enzyme Inhib. Med. Chem., 23, 144-148.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.1.7 amikacin
-
Homo sapiens
1.8.1.7 amoxicillin
-
Homo sapiens
1.8.1.7 clindamycin
-
Homo sapiens
1.8.1.7 Lincomycin
-
Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 ceftazidime competitive inhibition Homo sapiens
1.8.1.7 ceftriaxone competitive inhibition Homo sapiens
1.8.1.7 cefuroxime competitive inhibition Homo sapiens
1.8.1.7 chloramphenicol competitive inhibition Homo sapiens
1.8.1.7 Imipenem competitive inhibition Homo sapiens
1.8.1.7 ornidazole competitive inhibition Homo sapiens
1.8.1.7 rifamycin competitive inhibition Homo sapiens
1.8.1.7 sulfanylacetamide competitive inhibition Homo sapiens
1.8.1.7 Vancomycin noncompetitive inhibition Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.1.7 ammonium sulfate precipitation, 2',5'-ADP Sepharose 4B column chromatography and Sephadex G-200 gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 erythrocyte
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.1.7 0.01
-
hemolysate, at 25°C, pH 8.0 Homo sapiens
1.8.1.7 28
-
after 2800fold purification, at 25°C, pH 8.0 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+
-
Homo sapiens glutathione + NADP+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 EC 1.6.4.2 formerly Homo sapiens
1.8.1.7 glutathione reductase
-
Homo sapiens
1.8.1.7 NADPH:oxidized glutathione oxidoreductase
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 FAD
-
Homo sapiens
1.8.1.7 NADPH
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.8.1.7 0.06
-
Imipenem at 25°C, pH 8.0 Homo sapiens
1.8.1.7 0.085
-
sulfanylacetamide at 25°C, pH 8.0 Homo sapiens
1.8.1.7 0.275
-
rifamycin at 25°C, pH 8.0 Homo sapiens
1.8.1.7 3.59
-
ceftazidime at 25°C, pH 8.0 Homo sapiens
1.8.1.7 3.71
-
ceftriaxone at 25°C, pH 8.0 Homo sapiens
1.8.1.7 3.85
-
chloramphenicol at 25°C, pH 8.0 Homo sapiens
1.8.1.7 15.11
-
Vancomycin at 25°C, pH 8.0 Homo sapiens
1.8.1.7 23.5
-
cefuroxime at 25°C, pH 8.0 Homo sapiens
1.8.1.7 28.49
-
ornidazole at 25°C, pH 8.0 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.7 0.03
-
at 25°C, pH 8.0 Homo sapiens Imipenem
1.8.1.7 0.146
-
at 25°C, pH 8.0 Homo sapiens rifamycin
1.8.1.7 0.59
-
at 25°C, pH 8.0 Homo sapiens sulfanylacetamide
1.8.1.7 2.36
-
at 25°C, pH 8.0 Homo sapiens chloramphenicol
1.8.1.7 2.476
-
at 25°C, pH 8.0 Homo sapiens ceftazidime
1.8.1.7 2.88
-
at 25°C, pH 8.0 Homo sapiens ceftriaxone
1.8.1.7 4.83
-
at 25°C, pH 8.0 Homo sapiens Vancomycin
1.8.1.7 15.43
-
at 25°C, pH 8.0 Homo sapiens cefuroxime
1.8.1.7 19.63
-
at 25°C, pH 8.0 Homo sapiens ornidazole