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Literature summary extracted from

  • Ying, S.; Dong, S.; Kawada, A.; Kojima, T.; Chavanas, S.; Mechin, M.C.; Adoue, V.; Serre, G.; Simon, M.; Takahara, H.
    Transcriptional regulation of peptidylarginine deiminase expression in human keratinocytes (2009), J. Dermatol. Sci., 53, 2-9.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.3.15 Ca2+ Ca2+ is not only the indispensable factor in the environment of deimination reaction, but is also considered as a major regulator of PAD genes at the transcriptional level Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.15 Homo sapiens Q6TGC4
-
-
3.5.3.15 Homo sapiens Q9ULC6
-
-
3.5.3.15 Homo sapiens Q9ULW8
-
-
3.5.3.15 Homo sapiens Q9UM07
-
-
3.5.3.15 Homo sapiens Q9Y2J8
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.3.15 epidermis isoform PAD2 is mainly detected in both the spinous and granular layers with a more intense staining of the latter Homo sapiens
-
3.5.3.15 epidermis isoform PAD3 expression is restricted to the granular layer and lower stratum corneum Homo sapiens
-
3.5.3.15 epidermis PAD1 is detected in the entire epidermis with an increasing intensity gradient from the basal to the granular layer Homo sapiens
-
3.5.3.15 hair follicle inner root sheath and cuticle of the hair follicles Homo sapiens
-
3.5.3.15 keratinocyte
-
 Homo sapiens
-
3.5.3.15 medulla oblongata
-
 Homo sapiens
-
3.5.3.15 medulla oblongata isoform PAD3 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.15 filaggrin L-Arg + H2O
-
 Homo sapiens filaggrin citrulline + NH3
-
 ?
3.5.3.15 S100A3-L-arginine + H2O
-
 Homo sapiens S100A3-L-citrulline + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.3.15 PAD1 isoform Homo sapiens
3.5.3.15 PAD2 isoform Homo sapiens
3.5.3.15 PAD3 isoform Homo sapiens
3.5.3.15 PAD4 isoform Homo sapiens
3.5.3.15 PAD6 isoform Homo sapiens
3.5.3.15 peptidylarginine deiminase
-
 Homo sapiens