BRENDA - Enzyme Database

Transcriptional regulation of peptidylarginine deiminase expression in human keratinocytes

Ying, S.; Dong, S.; Kawada, A.; Kojima, T.; Chavanas, S.; Mechin, M.C.; Adoue, V.; Serre, G.; Simon, M.; Takahara, H.; J. Dermatol. Sci. 53, 2-9 (2009)

Data extracted from this reference:

Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.5.3.15
Ca2+
Ca2+ is not only the indispensable factor in the environment of deimination reaction, but is also considered as a major regulator of PAD genes at the transcriptional level; Ca2+ is not only the indispensable factor in the environment of deimination reaction, but is also considered as a major regulator of PAD genes at the transcriptional level; Ca2+ is not only the indispensable factor in the environment of deimination reaction, but is also considered as a major regulator of PAD genes at the transcriptional level; Ca2+ is not only the indispensable factor in the environment of deimination reaction, but is also considered as a major regulator of PAD genes at the transcriptional level; Ca2+ is not only the indispensable factor in the environment of deimination reaction, but is also considered as a major regulator of PAD genes at the transcriptional level
Homo sapiens
Organism
EC Number
Organism
UniProt
Commentary
Textmining
3.5.3.15
Homo sapiens
Q6TGC4
-
-
3.5.3.15
Homo sapiens
Q9ULC6
-
-
3.5.3.15
Homo sapiens
Q9ULW8
-
-
3.5.3.15
Homo sapiens
Q9UM07
-
-
3.5.3.15
Homo sapiens
Q9Y2J8
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.5.3.15
epidermis
isoform PAD2 is mainly detected in both the spinous and granular layers with a more intense staining of the latter; isoform PAD3 expression is restricted to the granular layer and lower stratum corneum; PAD1 is detected in the entire epidermis with an increasing intensity gradient from the basal to the granular layer
Homo sapiens
-
3.5.3.15
hair follicle
inner root sheath and cuticle of the hair follicles; inner root sheath and cuticle of the hair follicles
Homo sapiens
-
3.5.3.15
keratinocyte
-
Homo sapiens
-
3.5.3.15
medulla oblongata
; isoform PAD3
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
3.5.3.15
filaggrin L-Arg + H2O
-
699211
Homo sapiens
filaggrin citrulline + NH3
-
-
-
?
3.5.3.15
S100A3-L-arginine + H2O
-
699211
Homo sapiens
S100A3-L-citrulline + NH3
-
-
-
?
Synonyms
EC Number
Synonyms
Commentary
Organism
3.5.3.15
PAD1
isoform
Homo sapiens
3.5.3.15
PAD2
isoform
Homo sapiens
3.5.3.15
PAD3
isoform
Homo sapiens
3.5.3.15
PAD4
isoform
Homo sapiens
3.5.3.15
PAD6
isoform
Homo sapiens
3.5.3.15
peptidylarginine deiminase
-
Homo sapiens
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.5.3.15
Ca2+
Ca2+ is not only the indispensable factor in the environment of deimination reaction, but is also considered as a major regulator of PAD genes at the transcriptional level
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.5.3.15
epidermis
PAD1 is detected in the entire epidermis with an increasing intensity gradient from the basal to the granular layer
Homo sapiens
-
3.5.3.15
epidermis
isoform PAD3 expression is restricted to the granular layer and lower stratum corneum
Homo sapiens
-
3.5.3.15
epidermis
isoform PAD2 is mainly detected in both the spinous and granular layers with a more intense staining of the latter
Homo sapiens
-
3.5.3.15
hair follicle
inner root sheath and cuticle of the hair follicles
Homo sapiens
-
3.5.3.15
keratinocyte
-
Homo sapiens
-
3.5.3.15
medulla oblongata
isoform PAD3
Homo sapiens
-
3.5.3.15
medulla oblongata
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
3.5.3.15
filaggrin L-Arg + H2O
-
699211
Homo sapiens
filaggrin citrulline + NH3
-
-
-
?
3.5.3.15
S100A3-L-arginine + H2O
-
699211
Homo sapiens
S100A3-L-citrulline + NH3
-
-
-
?