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Literature summary extracted from
- Quantitative structure-activity relationship studies of mushroom tyrosinase inhibitors (2008), J. Comput. Aided Mol. Des., 22, 299-309.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.18.1 | (2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | - |
Agaricus bisporus |  |
| 1.14.18.1 | (2E)-3-(4-methoxyphenyl)prop-2-enoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | (2E)-3-phenylprop-2-enoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 2-hydroxy-4-methoxybenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 2-hydroxy-4-methylbenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 2-hydroxy-5-methoxybenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 2-hydroxy-5-methylbenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 2-Hydroxybenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 2-hydroxybenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 2-Methylbenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 2-Methylbenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 3-Hydroxybenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 3-Methoxybenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 3-methylbenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 3-methylbenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-(1-methylethyl)benzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-(1-methylethyl)benzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-(hexyloxy)benzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-(pentyloxy)benzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-butoxybenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-butylbenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-butylbenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-ethenylbenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-ethenylbenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-ethoxybenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-Ethylbenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-ethylbenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-heptylbenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-heptylbenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-hexylbenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-hexylbenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-hydroxybenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-hydroxybenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-methoxybenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-methoxybenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-methylbenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-methylbenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-octylbenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-octylbenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-pentylbenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-pentylbenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-propoxybenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-propylbenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-propylbenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-tert-butylbenzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | 4-tert-butylbenzoic acid | - |
Agaricus bisporus | |
| 1.14.18.1 | benzaldehyde | - |
Agaricus bisporus | |
| 1.14.18.1 | benzoic acid | - |
Agaricus bisporus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | Agaricus bisporus | - |
- |
- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | phenoloxidase | - |
Agaricus bisporus |
| 1.14.18.1 | tyrosinase | - |
Agaricus bisporus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.14.18.1 | 0.008 | - |
- |
Agaricus bisporus | 4-hexylbenzaldehyde | |
| 1.14.18.1 | 0.0088 | - |
- |
Agaricus bisporus | 4-heptylbenzaldehyde | |
| 1.14.18.1 | 0.01 | - |
- |
Agaricus bisporus | 4-octylbenzaldehyde | |
| 1.14.18.1 | 0.0135 | - |
- |
Agaricus bisporus | 4-pentylbenzaldehyde | |
| 1.14.18.1 | 0.023 | - |
- |
Agaricus bisporus | 4-ethenylbenzaldehyde | |
| 1.14.18.1 | 0.038 | - |
- |
Agaricus bisporus | 4-tert-butylbenzaldehyde | |
| 1.14.18.1 | 0.038 | - |
- |
Agaricus bisporus | 4-butylbenzaldehyde | |
| 1.14.18.1 | 0.075 | - |
- |
Agaricus bisporus | 4-propylbenzaldehyde | |
| 1.14.18.1 | 0.075 | - |
- |
Agaricus bisporus | 4-(1-methylethyl)benzaldehyde | |
| 1.14.18.1 | 0.082 | - |
- |
Agaricus bisporus | 4-octylbenzoic acid | |
| 1.14.18.1 | 0.095 | - |
- |
Agaricus bisporus | 4-Ethylbenzaldehyde | |
| 1.14.18.1 | 0.095 | - |
- |
Agaricus bisporus | 4-heptylbenzoic acid | |
| 1.14.18.1 | 0.11 | - |
- |
Agaricus bisporus | 4-hexylbenzoic acid | |
| 1.14.18.1 | 0.12 | - |
- |
Agaricus bisporus | 4-methylbenzaldehyde | |
| 1.14.18.1 | 0.12 | - |
- |
Agaricus bisporus | 4-pentylbenzoic acid | |
| 1.14.18.1 | 0.165 | - |
- |
Agaricus bisporus | 4-butylbenzoic acid | |
| 1.14.18.1 | 0.215 | - |
- |
Agaricus bisporus | 4-tert-butylbenzoic acid | |
| 1.14.18.1 | 0.225 | - |
- |
Agaricus bisporus | 4-(1-methylethyl)benzoic acid | |
| 1.14.18.1 | 0.235 | - |
- |
Agaricus bisporus | 4-propylbenzoic acid | |
| 1.14.18.1 | 0.29 | - |
- |
Agaricus bisporus | 4-ethylbenzoic acid | |
| 1.14.18.1 | 0.33 | - |
- |
Agaricus bisporus | 4-ethenylbenzoic acid | |
| 1.14.18.1 | 0.35 | - |
- |
Agaricus bisporus | 4-methoxybenzaldehyde | |
| 1.14.18.1 | 0.35 | - |
- |
Agaricus bisporus | 4-methylbenzoic acid | |
| 1.14.18.1 | 0.42 | - |
- |
Agaricus bisporus | 4-methoxybenzoic acid | |
| 1.14.18.1 | 0.42 | - |
- |
Agaricus bisporus | (2E)-3-(4-methoxyphenyl)prop-2-enoic acid | |
| 1.14.18.1 | 0.45 | - |
- |
Agaricus bisporus | 3-methylbenzaldehyde | |
| 1.14.18.1 | 0.5 | - |
- |
Agaricus bisporus | (2E)-3-(4-hydroxyphenyl)prop-2-enoic acid | |
| 1.14.18.1 | 0.58 | - |
- |
Agaricus bisporus | 3-methylbenzoic acid | |
| 1.14.18.1 | 0.8 | - |
- |
Agaricus bisporus | benzaldehyde | |
| 1.14.18.1 | 1 | - |
- |
Agaricus bisporus | benzoic acid | |
| 1.14.18.1 | 1.1 | - |
- |
Agaricus bisporus | 4-ethoxybenzoic acid | |
| 1.14.18.1 | 1.15 | - |
- |
Agaricus bisporus | 4-hydroxybenzaldehyde | |
| 1.14.18.1 | 1.15 | - |
- |
Agaricus bisporus | 4-(hexyloxy)benzoic acid | |
| 1.14.18.1 | 1.3 | - |
- |
Agaricus bisporus | 4-hydroxybenzoic acid | |
| 1.14.18.1 | 1.4 | - |
- |
Agaricus bisporus | 4-(pentyloxy)benzoic acid | |
| 1.14.18.1 | 1.65 | - |
- |
Agaricus bisporus | 2-hydroxy-4-methylbenzoic acid | |
| 1.14.18.1 | 1.65 | - |
- |
Agaricus bisporus | 4-butoxybenzoic acid | |
| 1.14.18.1 | 1.8 | - |
- |
Agaricus bisporus | 3-Methoxybenzaldehyde | |
| 1.14.18.1 | 1.85 | - |
- |
Agaricus bisporus | 4-propoxybenzoic acid | |
| 1.14.18.1 | 2.1 | - |
- |
Agaricus bisporus | (2E)-3-phenylprop-2-enoic acid | |
| 1.14.18.1 | 2.15 | - |
- |
Agaricus bisporus | 2-hydroxy-5-methylbenzoic acid | |
| 1.14.18.1 | 2.28 | - |
- |
Agaricus bisporus | 2-hydroxy-4-methoxybenzoic acid | |
| 1.14.18.1 | 2.56 | - |
- |
Agaricus bisporus | 2-Methylbenzoic acid | |
| 1.14.18.1 | 2.6 | - |
- |
Agaricus bisporus | 2-Methylbenzaldehyde | |
| 1.14.18.1 | 2.85 | - |
- |
Agaricus bisporus | 2-Hydroxybenzaldehyde | |
| 1.14.18.1 | 3.7 | - |
- |
Agaricus bisporus | 3-Hydroxybenzaldehyde | |
| 1.14.18.1 | 4.3 | - |
- |
Agaricus bisporus | 2-hydroxybenzoic acid | |
| 1.14.18.1 | 7.9 | - |
- |
Agaricus bisporus | 2-hydroxy-5-methoxybenzoic acid | |
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