Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Muhlia-Almazan, A.; Sanchez-Paz, A.; Garcia-Carreno, F.L.
    Invertebrate trypsins: a review (2008), J. Comp. Physiol. B, 178, 655-672.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.4 enteropeptidase trypsinogen is activated through the cleavage of a peptide Val-Asp-Asp-Asp-Asp-Lys-Ile located on the N-terminus of the protein, the heptapetide is cleaved autocatalytically by its physiological activator, enteropeptidase Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.4 HgCl2
-
Sesamia nonagrioides
3.4.21.4 Lima bean trypsin inhibitor
-
Rhynchophorus ferrugineus
3.4.21.4 Lima bean trypsin inhibitor
-
Sesamia nonagrioides
3.4.21.4 phenylmethylsulfonyl fluoride
-
Astacus astacus
3.4.21.4 phenylmethylsulfonyl fluoride
-
Penaeus japonicus
3.4.21.4 phenylmethylsulfonyl fluoride
-
Penaeus paulensis
3.4.21.4 phenylmethylsulfonyl fluoride
-
Rhynchophorus ferrugineus
3.4.21.4 phenylmethylsulfonyl fluoride
-
Rhyzopertha dominica
3.4.21.4 phenylmethylsulfonyl fluoride
-
Triatoma infestans
3.4.21.4 Soybean trypsin inhibitor
-
Penaeus japonicus
3.4.21.4 Soybean trypsin inhibitor
-
Rhynchophorus ferrugineus
3.4.21.4 Soybean trypsin inhibitor
-
Rhyzopertha dominica
3.4.21.4 Soybean trypsin inhibitor
-
Sesamia nonagrioides
3.4.21.4 Soybean trypsin inhibitor
-
Triatoma infestans
3.4.21.4 tosyl-L-lysyl chloromethyl ketone
-
Astacus astacus
3.4.21.4 tosyl-L-lysyl chloromethyl ketone
-
Penaeus japonicus
3.4.21.4 tosyl-L-lysyl chloromethyl ketone
-
Penaeus paulensis
3.4.21.4 tosyl-L-lysyl chloromethyl ketone
-
Rhyzopertha dominica
3.4.21.4 tosyl-L-lysyl chloromethyl ketone
-
Triops sp.
3.4.21.4 trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane
-
Rhyzopertha dominica
3.4.21.4 trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
Sesamia nonagrioides

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.4 additional information not dependent on Ca2+ for activation or stability Asterias amurensis
3.4.21.4 additional information not dependent on Ca2+ for activation or stability Musca domestica
3.4.21.4 additional information not dependent on Ca2+ for activation or stability Diatraea saccharalis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.4 21700
-
-
Penaeus paulensis
3.4.21.4 24000
-
-
Rhyzopertha dominica
3.4.21.4 25000
-
-
Astacus astacus
3.4.21.4 25000
-
-
Penaeus japonicus
3.4.21.4 25000
-
-
Manduca sexta
3.4.21.4 26000
-
-
Cancer pagurus
3.4.21.4 26600
-
-
Musca domestica
3.4.21.4 28000
-
-
Asterias amurensis
3.4.21.4 28700
-
-
Diatraea saccharalis
3.4.21.4 31000
-
-
Sesamia nonagrioides
3.4.21.4 31000
-
-
Triops sp.
3.4.21.4 32000
-
-
Penaeus vannamei
3.4.21.4 40000
-
-
Triatoma infestans

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.4 Aedes aegypti P29786
-
-
3.4.21.4 Astacus astacus
-
-
-
3.4.21.4 Asterias amurensis
-
-
-
3.4.21.4 Bos taurus
-
-
-
3.4.21.4 Cancer pagurus
-
-
-
3.4.21.4 Diaprepes abbreviatus O76498 Sugarcane rootstalk borer weevil
-
3.4.21.4 Diatraea saccharalis
-
-
-
3.4.21.4 Lepeophtheirus salmonis Q7YSS9 putative trypsin
-
3.4.21.4 Manduca sexta P35045 tobacco hornworm moth
-
3.4.21.4 Musca domestica
-
-
-
3.4.21.4 Penaeus japonicus
-
-
-
3.4.21.4 Penaeus paulensis
-
-
-
3.4.21.4 Penaeus vannamei Q9TY16 fragment; formerly Penaeus vannamei
-
3.4.21.4 Rhynchophorus ferrugineus
-
red palm weevil
-
3.4.21.4 Rhyzopertha dominica
-
-
-
3.4.21.4 Sesamia nonagrioides
-
-
-
3.4.21.4 Stomoxys calcitrans O76519
-
-
3.4.21.4 Stomoxys calcitrans O76520
-
-
3.4.21.4 Triatoma infestans
-
-
-
3.4.21.4 Triops sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.4 animal
-
Musca domestica
-
3.4.21.4 gastric juice
-
Cancer pagurus
-
3.4.21.4 gut
-
Rhynchophorus ferrugineus
-
3.4.21.4 hepatopancreas
-
Astacus astacus
-
3.4.21.4 hepatopancreas
-
Sesamia nonagrioides
-
3.4.21.4 hepatopancreas
-
Rhyzopertha dominica
-
3.4.21.4 hepatopancreas
-
Penaeus japonicus
-
3.4.21.4 hepatopancreas
-
Penaeus paulensis
-
3.4.21.4 hepatopancreas
-
Manduca sexta
-
3.4.21.4 hepatopancreas
-
Penaeus vannamei
-
3.4.21.4 midgut
-
Diatraea saccharalis
-
3.4.21.4 midgut
-
Stomoxys calcitrans
-
3.4.21.4 pancreas
-
Bos taurus
-
3.4.21.4 pyloric cecum
-
Asterias amurensis
-
3.4.21.4 salivary gland
-
Triatoma infestans
-
3.4.21.4 whole body
-
Triops sp.
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.4 midgut-specific serine protease 1
-
Stomoxys calcitrans
3.4.21.4 midgut-specific serine protease 2
-
Stomoxys calcitrans
3.4.21.4 trypsin 3A1
-
Aedes aegypti

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.4 7 8
-
Astacus astacus
3.4.21.4 7 9.5
-
Rhyzopertha dominica
3.4.21.4 8
-
-
Asterias amurensis
3.4.21.4 8
-
-
Cancer pagurus
3.4.21.4 8
-
-
Triops sp.
3.4.21.4 8 8.3
-
Penaeus japonicus
3.4.21.4 8.5
-
-
Musca domestica
3.4.21.4 8.5 10.5
-
Sesamia nonagrioides
3.4.21.4 9 10
-
Rhynchophorus ferrugineus
3.4.21.4 10.5
-
-
Diatraea saccharalis
3.4.21.4 10.5
-
-
Manduca sexta