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Literature summary extracted from

  • Parthasarathy, C.; Balasubramanian, K.
    Effects of corticosterone deficiency and its replacement on Leydig cell steroidogenesis (2008), J. Cell. Biochem., 104, 1671-1683.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.145 additional information 3beta-HSD mRNA level significantly increases in Leydig cells of corticosterone-deficient rats and simultaneous corticosterone treatment completely maintains the expression at control levels Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.64 additional information activity of 17beta-HSD is significantly decreased in metyrapone-induced corticosterone-deficient rat Leydig cells compared to control, whereas simultaneous administration of corticosterone partially prevented this and maintained the activity at near normal levels Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.64 Rattus norvegicus O54939
-
-
1.1.1.145 Rattus norvegicus P22071
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.64 Leydig cell
-
 Rattus norvegicus
-
1.1.1.145 Leydig cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.64 androstenedione + NADPH + H+
-
 Rattus norvegicus testosterone + NADP+
-
 ?
1.1.1.145 pregnenolone + NAD+
-
 Rattus norvegicus progesterone + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.64 17beta-HSD
-
 Rattus norvegicus
1.1.1.64 17beta-hydroxysteroid dehydrogenase
-
 Rattus norvegicus
1.1.1.145 3beta hydroxysteroid dehydrogenase
-
 Rattus norvegicus
1.1.1.145 3beta-HSD
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.64 NADH
-
 Rattus norvegicus
1.1.1.145 NADH
-
 Rattus norvegicus