Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Vieites, M.; Smircich, P.; Parajon-Costa, B.; Rodriguez, J.; Galaz, V.; Olea-Azar, C.; Otero, L.; Aguirre, G.; Cerecetto, H.; Gonzalez, M.; Gomez-Barrio, A.; Garat, B.; Gambino, D.
    Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an inhibitory effect on parasite-specific fumarate reductase (2008), J. Biol. Inorg. Chem., 13, 723-735.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.1.6 drug development lack of NADH-fumarate reductase in mammalian cells provides an interesting target against Chagas disease Trypanosoma cruzi

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.6 Pd-(pyridine-2-thiol N-oxide)2 inhibitory effect of metal-pyridine-2-thiol N-oxide complexes, marked increase is obeserved in the inhibitory effect with respect to that of the free ligand, inhibition in a dose-dependent manner, a clear relief of the growth inhibition produced by the metal-mpo complex is observed in the presence of 5 mM succinate Trypanosoma cruzi
1.3.1.6 Pt-(pyridine-2-thiol N-oxide)2 inhibitory effect of metal-pyridine-2-thiol N-oxide complexes, inhibition observed 2 is similar to that obtained with the ligand alone, a clear relief of the growth inhibition produced by the metal-mpo complex is observed in the presence of 5 mM succinate Trypanosoma cruzi
1.3.1.6 pyridine-2-thiol N-oxide 2-mercaptopyridine N-oxide (mpo) is a bioactive ligand with a potential as antitrypanosomal agent Trypanosoma cruzi
1.3.1.6 sodium pyridine-2-thiol N-oxide inhibitory effect of the sodium salt Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.6 fumarate + NADH + H+ Trypanosoma cruzi parasite-specific enzyme, succinate is one of the main respiratory substrates and is therefore required by the parasite for energy production succinate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.6 Trypanosoma cruzi
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.6 epimastigote
-
 Trypanosoma cruzi
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.6 fumarate + NADH + H+ parasite-specific enzyme, succinate is one of the main respiratory substrates and is therefore required by the parasite for energy production Trypanosoma cruzi succinate + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.6 NADH-fumarate reductase
-
 Trypanosoma cruzi

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.6 7
-
 assay at Trypanosoma cruzi