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Literature summary extracted from

  • Roussel, X.; Kriznik, A.; Richard, C.; Rahuel-Clermont, S.; Branlant, G.
    The catalytic mechanism of Sulfiredoxin from Saccharomyces cerevisiae passes through an oxidized disulfide Sulfiredoxin intermediate that is reduced by thioredoxin (2009), J. Biol. Chem., 284, 33048-33055.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.98.2
-
Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
1.8.98.2 C106A mutant, constructed to address questions regarding the catalytic mechanisms and the role of the cysteine residues Saccharomyces cerevisiae
1.8.98.2 C48A mutant, constructed to address questions regarding the catalytic mechanisms and the role of the cysteine residues Saccharomyces cerevisiae
1.8.98.2 C48A/C106A mutant, constructed to address questions regarding the catalytic mechanisms and the role of the cysteine residues Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.98.2 15000
-
Srx monomer, determined by SDS-PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH Saccharomyces cerevisiae
-
peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.8.98.2 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.98.2
-
Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH
-
Saccharomyces cerevisiae peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
?

Synonyms

EC Number Synonyms Comment Organism
1.8.98.2 Srx
-
Saccharomyces cerevisiae
1.8.98.2 sulfiredoxin
-
Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.98.2 ATP
-
Saccharomyces cerevisiae
1.8.98.2 dithiothreitol
-
Saccharomyces cerevisiae
1.8.98.2 thioredoxin
-
Saccharomyces cerevisiae