EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.21.75 | membrane-bound or soluble furin transiently expressed in HEK-293 cells | synthetic construct |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.75 | Chloroquine | weakly affects proprotein convertase activity and E3E2 processing. Additive inhibitory effect of chloroquine and decanoyl-RVKR-chloromethyl ketone on viral infection | synthetic construct | |
3.4.21.75 | decanoyl-RVKR-chloromethyl ketone | furin inhibitor, inhibits E3E2 cleavage. Additive inhibitory effect of chloroquine and decanoyl-RVKR-chloromethyl ketone on viral infection | synthetic construct |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.75 | 0.000036 | - |
viral precursor protein E3E2 | R64A mutant peptide of E3E2 from Asian Chikungunya virus strain | synthetic construct | |
3.4.21.75 | 0.000122 | - |
viral precursor protein E3E2 | wild-type E3E2 from Asian Chikungunya virus strain | synthetic construct |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.21.75 | membrane | - |
synthetic construct | 16020 | - |
3.4.21.75 | soluble | - |
synthetic construct | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.75 | synthetic construct | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.75 | viral precursor protein E3E2 | processes E3E2 from African Chikungunya virus strain at the HRQRR642ST site, whereas a Chikungunya virus strain of Asian origin is cleaved at site RRQRR642SI | synthetic construct | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.75 | Proprotein convertase | - |
synthetic construct |