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Literature summary extracted from

  • Bratland, E.; Bredholt, G.; Mellgren, G.; Knappskog, P.M.; Mozes, E.; Husebye, E.S.
    The purification and application of biologically active recombinant steroid cytochrome P450 21-hydroxylase: the major autoantigen in autoimmune Addisons disease (2009), J. Autoimmun., 33, 58-67.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.16 expressed in Spodoptera frugiperda insect cell microsomes using a baculovirus expression system Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.16 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.16 Homo sapiens P08686
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.14.16 HisTrap HP column chromatography (using Ni2+ ions immobilized onto a metal-chelating column) Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.16 serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.16 progesterone + NADPH + H+ + O2
-
 Homo sapiens deoxycorticosterone + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.16 21OH
-
 Homo sapiens
1.14.14.16 steroid cytochrome P450 21-hydroxylase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.16 cytochrome P450
-
 Homo sapiens
1.14.14.16 NADPH
-
 Homo sapiens