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Literature summary extracted from

  • Nishizawa, T.; Grüschow, S.; Jayamaha, D.H.; Nishizawa-Harada, C.; Sherman, D.H.
    Enzymatic assembly of the bis-indole core of rebeccamycin (2006), J. Am. Chem. Soc., 128, 724-725.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.21.98.2 expressed in Escherichia coli Lentzea aerocolonigenes

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.98.2 4 2-imino-3-(7-chloroindol-3-yl)propanoate + O2 Lentzea aerocolonigenes rebeccamycin biosynthetic pathway 2 dichlorochromopyrrolate + 2 NH3 + 2 H2O
-
 ?
1.21.98.2 4 2-imino-3-(7-chloroindol-3-yl)propanoate + O2 Lentzea aerocolonigenes ATCC 39243 rebeccamycin biosynthetic pathway 2 dichlorochromopyrrolate + 2 NH3 + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.98.2 Lentzea aerocolonigenes Q8KHV6
-
-
1.21.98.2 Lentzea aerocolonigenes ATCC 39243 Q8KHV6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.98.2 (2E)-2-[(E)-[1-carboxy-2-(1H-indol-3-yl)ethylidene]amino]-3-(2,3-dihydro-1H-indol-3-yl)prop-2-enoic acid + O2
-
 Lentzea aerocolonigenes 3-(2,3-dihydro-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid + NH3 + H2O
-
 ?
1.21.98.2 (2E)-2-[(E)-[1-carboxy-2-(1H-indol-3-yl)ethylidene]amino]-3-(2,3-dihydro-1H-indol-3-yl)prop-2-enoic acid + O2
-
 Lentzea aerocolonigenes ATCC 39243 3-(2,3-dihydro-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid + NH3 + H2O
-
 ?
1.21.98.2 (2E)-2-[(E)-[1-carboxy-2-(7-chloro-1H-indol-3-yl)ethylidene]amino]-3-(7-chloro-2,3-dihydro-1H-indol-3-yl)prop-2-enoic acid + O2
-
 Lentzea aerocolonigenes 3-(7-chloro-2,3-dihydro-1H-indol-3-yl)-4-(7-chloro-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid + NH3 + H2O
-
 ?
1.21.98.2 (2E)-2-[(E)-[1-carboxy-2-(7-chloro-1H-indol-3-yl)ethylidene]amino]-3-(7-chloro-2,3-dihydro-1H-indol-3-yl)prop-2-enoic acid + O2
-
 Lentzea aerocolonigenes ATCC 39243 3-(7-chloro-2,3-dihydro-1H-indol-3-yl)-4-(7-chloro-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid + NH3 + H2O
-
 ?
1.21.98.2 2-imino-3-(7-chloroindol-3-yl)propanoate + O2
-
 Lentzea aerocolonigenes dichlorochromopyrrolate + NH3 + H2O
-
 ?
1.21.98.2 2-imino-3-(7-chloroindol-3-yl)propanoate + O2
-
 Lentzea aerocolonigenes ATCC 39243 dichlorochromopyrrolate + NH3 + H2O
-
 ?
1.21.98.2 4 2-imino-3-(7-chloroindol-3-yl)propanoate + O2
-
 Lentzea aerocolonigenes 2 dichlorochromopyrrolate + 2 NH3 + 2 H2O
-
 ?
1.21.98.2 4 2-imino-3-(7-chloroindol-3-yl)propanoate + O2 rebeccamycin biosynthetic pathway Lentzea aerocolonigenes 2 dichlorochromopyrrolate + 2 NH3 + 2 H2O
-
 ?
1.21.98.2 4 2-imino-3-(7-chloroindol-3-yl)propanoate + O2
-
 Lentzea aerocolonigenes ATCC 39243 2 dichlorochromopyrrolate + 2 NH3 + 2 H2O
-
 ?
1.21.98.2 4 2-imino-3-(7-chloroindol-3-yl)propanoate + O2 rebeccamycin biosynthetic pathway Lentzea aerocolonigenes ATCC 39243 2 dichlorochromopyrrolate + 2 NH3 + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.98.2 RebD
-
 Lentzea aerocolonigenes

Cofactor

EC Number Cofactor Comment Organism Structure
1.21.98.2 flavin
-
 Lentzea aerocolonigenes
1.21.98.2 heme
-
 Lentzea aerocolonigenes
1.21.98.2 heme the cytochrome cofactor is noncovalently bound to the enzyme Lentzea aerocolonigenes

General Information

EC Number General Information Comment Organism
1.21.98.2 metabolism a key enzyme in the biosynthetic pathways leading to indolocarbazole natural products Lentzea aerocolonigenes