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Literature summary extracted from
- Neutrophil elastase (NE) and NE inhibitors: canonical and noncanonical functions in lung chronic inflammatory diseases (cystic fibrosis and chronic obstructive pulmonary disease) (2008), J. Aerosol Med. Pulm. Drug Deliv., 21, 125-144.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.37 | C5a | - |
Homo sapiens | |
| 3.4.21.37 | fMLP peptide | a tripeptide derived from bacterial wall | Homo sapiens | |
| 3.4.21.37 | interleukin-8 | - |
Homo sapiens | |
| 3.4.21.37 | lipopolysaccharide | - |
Homo sapiens |  |
| 3.4.21.37 | tumour necrosis factor alpha | - |
Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.37 | alpha-1-protease inhibitor | also called alpha-1-antitrypsin | Homo sapiens | |
| 3.4.21.37 | elafin | also known as elastase specific inhibitor, skin-derived antileukoprotease, or trappin-2 | Homo sapiens | |
| 3.4.21.37 | secretory leukocyte protease inhibitor | - |
Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.37 | azurophil granule | - |
Homo sapiens | 42582 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.37 | Collagen + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | Elastin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | Fibronectin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | Laminin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.37 | additional information | Homo sapiens | neutrophil elastase possesses potent microbicidal activity, and is speculated to assist with phagocytosis of pathogens by activated neutrophils, moreover, neutrophil elastase can indirectly help the host eradication of pathogens by upregulating the expression of potent antiprotease/antimicrobial agents such as elafin, secretory leukocyte protease inhibitor, and human beta defensin-2 | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.37 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.37 | monocyte | small amounts of the enzyme are expressed by monocytes | Homo sapiens | - |
| 3.4.21.37 | neutrophil | most abundant in neutrophils | Homo sapiens | - |
| 3.4.21.37 | T-lymphocyte | small amounts of the enzyme are expressed by T-lymphocytes | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.37 | Collagen + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | Laminin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.37 | additional information | neutrophil elastase possesses potent microbicidal activity, and is speculated to assist with phagocytosis of pathogens by activated neutrophils, moreover, neutrophil elastase can indirectly help the host eradication of pathogens by upregulating the expression of potent antiprotease/antimicrobial agents such as elafin, secretory leukocyte protease inhibitor, and human beta defensin-2 | Homo sapiens | ? | - |
? | |
| 3.4.21.37 | N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Homo sapiens | N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.37 | neutrophil elastase | - |
Homo sapiens |
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