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Literature summary extracted from

  • Liu, X.; Kramer, J.A.; Hu, Y.; Schmidt, J.M.; Jiang, J.; Wilson, A.G.E.
    Development of a high-throughput human hepG2 dual luciferase assay for detection of metabolically activated hepatotoxicants and genotoxicants (2009), Int. J. Toxicol., 28, 162-179.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.13.12.5 pharmacology used as an assay for assessing potential liver toxicity by measuring GADD45-beta induction as an control for increased DNA damage Renilla sp.

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.12.5 expression in Hep-G2 cell Renilla sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.12.5 2-acetylaminofluorene
-
 Renilla sp.
1.13.12.5 2-aminoanthracene
-
 Renilla sp.
1.13.12.5 2-nitrofluorene
-
 Renilla sp.
1.13.12.5 4-acetylaminofluorene
-
 Renilla sp.
1.13.12.5 4-nitroquinoline-N-oxide
-
 Renilla sp.
1.13.12.5 acetaminophen
-
 Renilla sp.
1.13.12.5 actinomycin D
-
 Renilla sp.
1.13.12.5 albendazole
-
 Renilla sp.
1.13.12.5 amiodarone
-
 Renilla sp.
1.13.12.5 ara C
-
 Renilla sp.
1.13.12.5 arsenic III oxide
-
 Renilla sp.
1.13.12.5 bleomycin
-
 Renilla sp.
1.13.12.5 carbamzepine
-
 Renilla sp.
1.13.12.5 chlorambucil
-
 Renilla sp.
1.13.12.5 chlorpromazine
-
 Renilla sp.
1.13.12.5 cisplatin
-
 Renilla sp.
1.13.12.5 cyclophosphamide
-
 Renilla sp.
1.13.12.5 cyclosporin A
-
 Renilla sp.
1.13.12.5 cytochalasin B
-
 Renilla sp.
1.13.12.5 digoxin
-
 Renilla sp.
1.13.12.5 dimethylnitrosamine
-
 Renilla sp.
1.13.12.5 ethyl methanesulfonate
-
 Renilla sp.
1.13.12.5 etoposide
-
 Renilla sp.
1.13.12.5 gemfibrozil
-
 Renilla sp.
1.13.12.5 haloperidol
-
 Renilla sp.
1.13.12.5 methylmethane sulfonate
-
 Renilla sp.
1.13.12.5 mitomycin
-
 Renilla sp.
1.13.12.5 N-methyl-N'-nitro-nitroso-guanidin
-
 Renilla sp.
1.13.12.5 nefazodone
-
 Renilla sp.
1.13.12.5 phenytoin
-
 Renilla sp.
1.13.12.5 Sodium azide
-
 Renilla sp.
1.13.12.5 tacrine
-
 Renilla sp.
1.13.12.5 taxol
-
 Renilla sp.
1.13.12.5 troglitazone
-
 Renilla sp.
1.13.12.5 Valproic acid
-
 Renilla sp.
1.13.12.5 vinblastin
-
 Renilla sp.

Organism

EC Number Organism UniProt Comment Textmining
1.13.12.5 Renilla sp.
-
-
-

Synonyms

EC Number Synonyms Comment Organism
1.13.12.5 firefly luciferase
-
 Renilla sp.
1.13.12.5 Renilla luciferase
-
 Renilla sp.