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Development of a high-throughput human hepG2 dual luciferase assay for detection of metabolically activated hepatotoxicants and genotoxicants

Liu, X.; Kramer, J.A.; Hu, Y.; Schmidt, J.M.; Jiang, J.; Wilson, A.G.E.; Int. J. Toxicol. 28, 162-179 (2009)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
1.13.12.5
pharmacology
used as an assay for assessing potential liver toxicity by measuring GADD45-beta induction as an control for increased DNA damage
Renilla sp.
Cloned(Commentary)
EC Number
Commentary
Organism
1.13.12.5
expression in Hep-G2 cell
Renilla sp.
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.13.12.5
2-acetylaminofluorene
-
Renilla sp.
1.13.12.5
2-aminoanthracene
-
Renilla sp.
1.13.12.5
2-nitrofluorene
-
Renilla sp.
1.13.12.5
4-acetylaminofluorene
-
Renilla sp.
1.13.12.5
4-nitroquinoline-N-oxide
-
Renilla sp.
1.13.12.5
acetaminophen
-
Renilla sp.
1.13.12.5
actinomycin D
-
Renilla sp.
1.13.12.5
albendazole
-
Renilla sp.
1.13.12.5
amiodarone
-
Renilla sp.
1.13.12.5
ara C
-
Renilla sp.
1.13.12.5
arsenic III oxide
-
Renilla sp.
1.13.12.5
bleomycin
-
Renilla sp.
1.13.12.5
carbamzepine
-
Renilla sp.
1.13.12.5
chlorambucil
-
Renilla sp.
1.13.12.5
chlorpromazine
-
Renilla sp.
1.13.12.5
cisplatin
-
Renilla sp.
1.13.12.5
cyclophosphamide
-
Renilla sp.
1.13.12.5
cyclosporin A
-
Renilla sp.
1.13.12.5
cytochalasin B
-
Renilla sp.
1.13.12.5
digoxin
-
Renilla sp.
1.13.12.5
dimethylnitrosamine
-
Renilla sp.
1.13.12.5
ethyl methanesulfonate
-
Renilla sp.
1.13.12.5
etoposide
-
Renilla sp.
1.13.12.5
gemfibrozil
-
Renilla sp.
1.13.12.5
haloperidol
-
Renilla sp.
1.13.12.5
methylmethane sulfonate
-
Renilla sp.
1.13.12.5
mitomycin
-
Renilla sp.
1.13.12.5
N-methyl-N'-nitro-nitroso-guanidin
-
Renilla sp.
1.13.12.5
nefazodone
-
Renilla sp.
1.13.12.5
phenytoin
-
Renilla sp.
1.13.12.5
Sodium azide
-
Renilla sp.
1.13.12.5
tacrine
-
Renilla sp.
1.13.12.5
taxol
-
Renilla sp.
1.13.12.5
troglitazone
-
Renilla sp.
1.13.12.5
Valproic acid
-
Renilla sp.
1.13.12.5
vinblastin
-
Renilla sp.
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.13.12.5
Renilla sp.
-
-
-
Application (protein specific)
EC Number
Application
Commentary
Organism
1.13.12.5
pharmacology
used as an assay for assessing potential liver toxicity by measuring GADD45-beta induction as an control for increased DNA damage
Renilla sp.
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
1.13.12.5
expression in Hep-G2 cell
Renilla sp.
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.13.12.5
2-acetylaminofluorene
-
Renilla sp.
1.13.12.5
2-aminoanthracene
-
Renilla sp.
1.13.12.5
2-nitrofluorene
-
Renilla sp.
1.13.12.5
4-acetylaminofluorene
-
Renilla sp.
1.13.12.5
4-nitroquinoline-N-oxide
-
Renilla sp.
1.13.12.5
acetaminophen
-
Renilla sp.
1.13.12.5
actinomycin D
-
Renilla sp.
1.13.12.5
albendazole
-
Renilla sp.
1.13.12.5
amiodarone
-
Renilla sp.
1.13.12.5
ara C
-
Renilla sp.
1.13.12.5
arsenic III oxide
-
Renilla sp.
1.13.12.5
bleomycin
-
Renilla sp.
1.13.12.5
carbamzepine
-
Renilla sp.
1.13.12.5
chlorambucil
-
Renilla sp.
1.13.12.5
chlorpromazine
-
Renilla sp.
1.13.12.5
cisplatin
-
Renilla sp.
1.13.12.5
cyclophosphamide
-
Renilla sp.
1.13.12.5
cyclosporin A
-
Renilla sp.
1.13.12.5
cytochalasin B
-
Renilla sp.
1.13.12.5
digoxin
-
Renilla sp.
1.13.12.5
dimethylnitrosamine
-
Renilla sp.
1.13.12.5
ethyl methanesulfonate
-
Renilla sp.
1.13.12.5
etoposide
-
Renilla sp.
1.13.12.5
gemfibrozil
-
Renilla sp.
1.13.12.5
haloperidol
-
Renilla sp.
1.13.12.5
methylmethane sulfonate
-
Renilla sp.
1.13.12.5
mitomycin
-
Renilla sp.
1.13.12.5
N-methyl-N'-nitro-nitroso-guanidin
-
Renilla sp.
1.13.12.5
nefazodone
-
Renilla sp.
1.13.12.5
phenytoin
-
Renilla sp.
1.13.12.5
Sodium azide
-
Renilla sp.
1.13.12.5
tacrine
-
Renilla sp.
1.13.12.5
taxol
-
Renilla sp.
1.13.12.5
troglitazone
-
Renilla sp.
1.13.12.5
Valproic acid
-
Renilla sp.
1.13.12.5
vinblastin
-
Renilla sp.