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Literature summary extracted from

  • Babajan, B.; Anuradha, C.; Chaitanya, M.; Gowsia, D.; Kumar, C.
    In silico structural characterization of Mycobacterium tuberculosis H37Rv UDP-N-acetylmuramate dehydrogenase (2009), Int. J. Integr. Biol., 6, 12-16.
No PubMed abstract available

Application

EC Number Application Comment Organism
1.3.1.98 medicine computional design of 3-D structures of MurB enzymes and docking studies will provide highly useful information towards rational design of new tuberculosis drugs through experimental research design for further formulations as per pharmaceutical norms Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.3.1.98 sequence alignment with Escherichia coli structures, PDB entries 2Q85 and 2MBR, and modeling of structure as well as docking with N-acetylpyruvyl glucosamine Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.98 Mycobacterium tuberculosis
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1.3.1.98 Mycobacterium tuberculosis B5AFK3
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1.3.1.98 Mycobacterium tuberculosis H37Rv B5AFK3
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.98 UDP-N-acetylenolpyruvylglucosamine + NADPH complex of MurB and substrate forms strong hydrogen bond with Arg176, Ser257 and Glu361. The secondary structure of MurB consists of 13 helices, 6 beta sheets, 6 beta hairpins, 5 beta bluges, 19 stands, 52 beta turns and 4 inverse gamma turns Mycobacterium tuberculosis UDP-N-acetylmuramic acid + NADP+
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.98 MurB
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.98 FAD
-
 Mycobacterium tuberculosis