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Literature summary extracted from

  • Pascual, I.; Larrayoz, I.M.; Rodriguez, I.R.
    Retinoic acid regulates the human methionine sulfoxide reductase A (MSRA) gene via two distinct promoters (2009), Genomics, 93, 62-71.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.4.11 cytosol
-
 Homo sapiens 5829
-
1.8.4.11 mitochondrion
-
 Homo sapiens 5739
-
1.8.4.11 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.11 L-methionine (S)-sulfoxide + thioredoxin Homo sapiens
-
 L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Homo sapiens Q9UJ68
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.11 brain
-
 Homo sapiens
-
1.8.4.11 D-407 cell
-
 Homo sapiens
-
1.8.4.11 HEK-293 cell
-
 Homo sapiens
-
1.8.4.11 kidney
-
 Homo sapiens
-
1.8.4.11 SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 L-methionine (S)-sulfoxide + thioredoxin
-
 Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 methionine sulfoxide reductase A
-
 Homo sapiens
1.8.4.11 MsrA
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 thioredoxin
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.8.4.11 Homo sapiens the upstream (promoter 1) regulates the msrA1 transcript that codes for the mitochondrial form of MSRA, the downstream promoter (promoter 2) regulates the msrA2/3 transcripts that code for the cytosolic/nuclear forms of MSRA and is generally less active, both promoters are partially regulated by all-trans retinoic acid up