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Literature summary extracted from

  • Chew, E.H.; Nagle, A.A.; Zhang, Y.; Scarmagnani, S.; Palaniappan, P.; Bradshaw, T.D.; Holmgren, A.; Westwell, A.D.
    Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention (2010), Free Radic. Biol. Med., 48, 98-111.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.9 2-benzoyloxycinnamaldehyde
-
 Escherichia coli
1.8.1.9 2-benzoyloxycinnamaldehyde
-
 Homo sapiens
1.8.1.9 2-benzoyloxycinnamaldehyde
-
 Rattus norvegicus
1.8.1.9 2-benzyloxycinnamaldehyde
-
 Homo sapiens
1.8.1.9 2-benzyloxycinnamaldehyde
-
 Rattus norvegicus
1.8.1.9 2-hydroxycinnamaldehyde
-
 Homo sapiens
1.8.1.9 2-hydroxycinnamaldehyde
-
 Rattus norvegicus
1.8.1.9 2-pentoxycinnamaldehyde
-
 Homo sapiens
1.8.1.9 2-pentoxycinnamaldehyde
-
 Rattus norvegicus
1.8.1.9 5-fluoro-2-hydroxycinnamaldehyde
-
 Escherichia coli
1.8.1.9 5-fluoro-2-hydroxycinnamaldehyde
-
 Homo sapiens
1.8.1.9 5-fluoro-2-hydroxycinnamaldehyde
-
 Rattus norvegicus
1.8.1.9 additional information not inhibited by trans-cinnamaldehyde and 2-hydroxycinnamaldehyde after 1 h of incubation Escherichia coli
1.8.1.9 additional information not inhibited by 2-methoxycinnamaldehyde and cinnamic acid Homo sapiens
1.8.1.9 additional information not inhibited by 2-methoxycinnamaldehyde and cinnamic acid after 1 h of incubation Rattus norvegicus
1.8.1.9 trans-cinnamaldehyde
-
 Homo sapiens
1.8.1.9 trans-cinnamaldehyde
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Escherichia coli
-
-
-
1.8.1.9 Homo sapiens
-
-
-
1.8.1.9 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.9 HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 5,5'-dithiobis-(2-nitrobenzoic acid) + NADPH + H+
-
 Escherichia coli 2-nitro-5-thiobenzoate + NADP+
-
 ?
1.8.1.9 5,5'-dithiobis-(2-nitrobenzoic acid) + NADPH + H+
-
 Homo sapiens 2-nitro-5-thiobenzoate + NADP+
-
 ?
1.8.1.9 5,5'-dithiobis-(2-nitrobenzoic acid) + NADPH + H+
-
 Rattus norvegicus 2-nitro-5-thiobenzoate + NADP+
-
 ?
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
 Escherichia coli ?
-
 ?
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
 Homo sapiens ?
-
 ?
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase
-
 Escherichia coli
1.8.1.9 thioredoxin reductase
-
 Homo sapiens
1.8.1.9 thioredoxin reductase
-
 Rattus norvegicus
1.8.1.9 TrxR
-
 Escherichia coli
1.8.1.9 TrxR
-
 Homo sapiens
1.8.1.9 TrxR
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 NADPH
-
 Escherichia coli
1.8.1.9 NADPH
-
 Homo sapiens
1.8.1.9 NADPH
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.9 0.007
-
 1 h incubation with recombinant TrxR, in TE buffer, at 25°C Rattus norvegicus 5-fluoro-2-hydroxycinnamaldehyde
1.8.1.9 0.017
-
 1 h incubation with recombinant TrxR, in TE buffer, at 25°C Rattus norvegicus 2-benzoyloxycinnamaldehyde
1.8.1.9 0.0253
-
 1 h incubation with recombinant TrxR, in TE buffer, at 25°C Rattus norvegicus 2-hydroxycinnamaldehyde
1.8.1.9 0.0636
-
 1 h incubation with recombinant TrxR, in TE buffer, at 25°C Rattus norvegicus 2-benzyloxycinnamaldehyde
1.8.1.9 0.0713
-
 1 h incubation with recombinant TrxR, in TE buffer, at 25°C Rattus norvegicus trans-cinnamaldehyde
1.8.1.9 0.0844
-
 1 h incubation with recombinant TrxR, in TE buffer, at 25°C Escherichia coli 5-fluoro-2-hydroxycinnamaldehyde
1.8.1.9 0.0994
-
 1 h incubation with recombinant TrxR, in TE buffer, at 25°C Escherichia coli 2-benzoyloxycinnamaldehyde
1.8.1.9 0.1
-
 1 h incubation with recombinant TrxR, in TE buffer, at 25°C Rattus norvegicus 2-pentoxycinnamaldehyde