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Literature summary extracted from

  • Rengby, O.; Cheng, Q.; Vahter, M.; Joernvall, H.; Arner, E.S.
    Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1 (2009), Free Radic. Biol. Med., 46, 893-904.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.1.9 expressed in Escherichia coli BL21(DE3) cells Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.1.9 0.0032
-
thioredoxin disulfide purified, recombinant, tetrameric enzyme Rattus norvegicus
1.8.1.9 0.0036
-
thioredoxin disulfide purified, recombinant, dimeric enzyme Rattus norvegicus
1.8.1.9 0.139
-
5,5'-dithiobis(2-nitrobenzoic acid) purified, recombinant, tetrameric enzyme Rattus norvegicus
1.8.1.9 0.2156
-
5,5'-dithiobis(2-nitrobenzoic acid) purified, recombinant, dimeric enzyme Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.1.9 selenium TrxR1 is a selenoprotein that contains a selenocysteine residue at the penultimate C-terminal Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.1.9 54386
-
2 * 54386, highly active enzyme form, calculated from amino acid sequence Rattus norvegicus
1.8.1.9 150000
-
highly active enzyme form, gel filtration Rattus norvegicus
1.8.1.9 250000
-
low-activity enzyme form, gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Rattus norvegicus O89049
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.1.9 2',5'-ADP Sepharose column chromatography and phenylarsine oxide Sepharose column chromatography Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
Rattus norvegicus 2-nitro-5-thiobenzoate + NADP+
-
?
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
Rattus norvegicus thioredoxin + NADP+
-
?

Subunits

EC Number Subunits Comment Organism
1.8.1.9 homodimer 2 * 54386, highly active enzyme form, calculated from amino acid sequence Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase 1
-
Rattus norvegicus
1.8.1.9 TrxR1
-
Rattus norvegicus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.8.1.9 33.08
-
5,5'-dithiobis(2-nitrobenzoic acid) purified, recombinant, tetrameric enzyme Rattus norvegicus
1.8.1.9 47 73 thioredoxin disulfide purified, recombinant, tetrameric enzyme Rattus norvegicus
1.8.1.9 106.3
-
5,5'-dithiobis(2-nitrobenzoic acid) purified, recombinant, dimeric enzyme Rattus norvegicus
1.8.1.9 114.1
-
thioredoxin disulfide purified, recombinant, dimeric enzyme Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 FAD
-
Rattus norvegicus
1.8.1.9 NADPH
-
Rattus norvegicus

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.8.1.9 183.3
-
5,5'-dithiobis(2-nitrobenzoic acid) purified, recombinant, tetrameric enzyme Rattus norvegicus
1.8.1.9 495
-
5,5'-dithiobis(2-nitrobenzoic acid) purified, recombinant, dimeric enzyme Rattus norvegicus
1.8.1.9 14920
-
thioredoxin disulfide purified, recombinant, tetrameric enzyme Rattus norvegicus
1.8.1.9 31700
-
thioredoxin disulfide purified, recombinant, dimeric enzyme Rattus norvegicus