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Literature summary extracted from

  • dos Reis, F.C.; Smith, B.O.; Santos, C.C.; Costa, T.F.; Scharfstein, J.; Coombs, G.H.; Mottram, J.C.; Lima, A.P.
    The role of conserved residues of chagasin in the inhibition of cysteine peptidases (2008), FEBS Lett., 582, 485-490.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.15 chagasin
-
 Homo sapiens
3.4.22.15 chagasin mutant delta T31-T32
-
 Homo sapiens
3.4.22.15 chagasin mutant P30A
-
 Homo sapiens
3.4.22.15 chagasin mutant T31A
-
 Homo sapiens
3.4.22.15 chagasin mutant T31A/T32A
-
 Homo sapiens
3.4.22.15 chagasin mutant T31S
-
 Homo sapiens
3.4.22.15 chagasin mutant T31V
-
 Homo sapiens
3.4.22.15 chagasin mutant T31Y
-
 Homo sapiens
3.4.22.15 chagasin mutant T32A
-
 Homo sapiens
3.4.22.15 chagasin mutant T32S
-
 Homo sapiens
3.4.22.15 chagasin mutant T32V
-
 Homo sapiens
3.4.22.15 chagasin mutant T32Y
-
 Homo sapiens
3.4.22.15 chagasin mutant W93A
-
 Homo sapiens
3.4.22.51 chagasin
-
 Trypanosoma cruzi
3.4.22.51 chagasin mutant delta T31-T32
-
 Trypanosoma cruzi
3.4.22.51 chagasin mutant P30A
-
 Trypanosoma cruzi
3.4.22.51 chagasin mutant T31A
-
 Trypanosoma cruzi
3.4.22.51 chagasin mutant T31A/T32A
-
 Trypanosoma cruzi
3.4.22.51 chagasin mutant T31S
-
 Trypanosoma cruzi
3.4.22.51 chagasin mutant T31V
-
 Trypanosoma cruzi
3.4.22.51 chagasin mutant T31Y
-
 Trypanosoma cruzi
3.4.22.51 chagasin mutant T32A
-
 Trypanosoma cruzi
3.4.22.51 chagasin mutant T32E
-
 Trypanosoma cruzi
3.4.22.51 chagasin mutant T32S
-
 Trypanosoma cruzi
3.4.22.51 chagasin mutant T32V
-
 Trypanosoma cruzi
3.4.22.51 chagasin mutant T32Y
-
 Trypanosoma cruzi
3.4.22.51 chagasin mutant W93A
-
 Trypanosoma cruzi
3.4.22.51 chagasin mutant Y89F
-
 Trypanosoma cruzi
3.4.22.51 chagasin mutant Y89S
-
 Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.15 Homo sapiens
-
-
-
3.4.22.51 Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.15 Z-Phe-Arg-7-amido-4-methyl-coumarin + H2O 5 microM, pH 6.5, 28°C Homo sapiens ?
-
 ?
3.4.22.51 Z-Phe-Arg-7-amido-4-methylcoumarin + H2O 5 microM, pH 6.5, 28°C Trypanosoma cruzi ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.15 cathepsin L
-
 Homo sapiens
3.4.22.15 human cathepsin L
-
 Homo sapiens
3.4.22.51 cruzipain
-
 Trypanosoma cruzi
3.4.22.51 family C1 cysteine peptidase
-
 Trypanosoma cruzi

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.15 28
-
 assay at pH 6.5 Homo sapiens
3.4.22.51 28
-
 assay at pH 6.5 Trypanosoma cruzi

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.15 6.5
-
 assay at 28°C Homo sapiens
3.4.22.51 6.5
-
 assay at 28°C Trypanosoma cruzi

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.22.15 0.0000000018
-
 chagasin mutant T31A/T32A
-
 Homo sapiens
3.4.22.15 0.0000000027
-
 chagasin mutant T32Y
-
 Homo sapiens
3.4.22.15 0.0000000039
-
 chagasin mutant T31A
-
 Homo sapiens
3.4.22.15 0.0000000049
-
 chagasin mutant T31S
-
 Homo sapiens
3.4.22.15 0.0000000068
-
 chagasin mutant T31Y
-
 Homo sapiens
3.4.22.15 0.0000000073
-
 chagasin
-
 Homo sapiens
3.4.22.15 0.0000000097
-
 chagasin mutant T31V
-
 Homo sapiens
3.4.22.15 0.000000014
-
 chagasin mutant T32A
-
 Homo sapiens
3.4.22.15 0.00000002
-
 chagasin mutant T32V
-
 Homo sapiens
3.4.22.15 0.000000032
-
 chagasin mutant T32S
-
 Homo sapiens
3.4.22.15 0.000000045
-
 chagasin mutant P30A
-
 Homo sapiens
3.4.22.15 0.000000825
-
 chagasin mutant W93A
-
 Homo sapiens
3.4.22.15 0.0000022
-
 chagasin mutant deltaT31-T32
-
 Homo sapiens
3.4.22.51 0.0000000076
-
 chagasin
-
 Trypanosoma cruzi
3.4.22.51 0.000000011
-
 chagasin mutant T31S
-
 Trypanosoma cruzi
3.4.22.51 0.000000011
-
 chagasin mutant T32E
-
 Trypanosoma cruzi
3.4.22.51 0.000000016
-
 chagasin mutant T32A
-
 Trypanosoma cruzi
3.4.22.51 0.000000016
-
 chagasin mutant T32Y
-
 Trypanosoma cruzi
3.4.22.51 0.00000002
-
 chagasin mutant P30A
-
 Trypanosoma cruzi
3.4.22.51 0.00000002
-
 chagasin mutant T32S
-
 Trypanosoma cruzi
3.4.22.51 0.00000002
-
 chagasin mutant Y89F
-
 Trypanosoma cruzi
3.4.22.51 0.000000025
-
 chagasin mutant Y89S
-
 Trypanosoma cruzi
3.4.22.51 0.000000031
-
 chagasin mutant W93A
-
 Trypanosoma cruzi
3.4.22.51 0.00000007
-
 chagasin mutant T31V
-
 Trypanosoma cruzi
3.4.22.51 0.000000193
-
 chagasin mutant T32V
-
 Trypanosoma cruzi
3.4.22.51 0.000000317
-
 chagasin mutant T31A
-
 Trypanosoma cruzi
3.4.22.51 0.000000747
-
 chagasin mutant T31Y
-
 Trypanosoma cruzi
3.4.22.51 0.000001065
-
 chagasin mutant T31A/T32A
-
 Trypanosoma cruzi
3.4.22.51 0.000005868
-
 chagasin mutant deltaT31-T32
-
 Trypanosoma cruzi