EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.2.3.1 | additional information | knock-down of isoform AOX1 by siRNA impairs adipogenesis and reduces adiponectin release | Mus musculus |
1.2.3.1 | additional information | knock-down of isoform AOX1 by siRNA impairs adipogenesis and reduces adiponectin release | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.3.1 | fenofibrate | in mature adipocytes, enzyme expression is reduced in presence of 50 microM fenofibrate | Homo sapiens | |
1.2.3.1 | fenofibrate | in mature adipocytes, enzyme expression is reduced in presence of 50 microM fenofibrate | Mus musculus | |
1.2.3.1 | palmitic acid | enzyme expression is reduced in 3T3-L1 cells differentiated in presence of 400 microM palmitic acid | Homo sapiens | |
1.2.3.1 | palmitic acid | enzyme expression is reduced in 3T3-L1 cells differentiated in presence of 400 microM palmitic acid | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.3.1 | Homo sapiens | - |
- |
- |
1.2.3.1 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.3.1 | 3T3-L1 cell | preadipocytes have a very low expression of AOX1, in 2 days differentiated cells AOX1 is induced and is not further upregulated in 3, 7 and 9 days differentiated cells. AOX1 mRNA is nearly four-fold higher in 2 days differentiated cells when compared to preadipocytes and doubles from days 2 to 6 | Mus musculus | - |
1.2.3.1 | adipose tissue | isoform AOX1 mRNA is higher in visceral compared to subcutaneous adipose tissue, Aox1 protein is detected in both fat depots | Homo sapiens | - |